COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM.
|Sequence||One Letter Code: Ac-LRVRLASHLRKLRKRLL-NH2|
Three Letter Code: Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2
|Biological Activity||Apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).|
|Storage||Desiccate at -20°C||Solubility||Soluble to 1 mg/ml in water||Shipping Condition||Room temperature in continental US; may vary elsewhere.|
|CAT#||Product Name||M.W||Molecular Formula||Inquiry|
|R1172||Adrenomedullin (AM) (13-52), human||Inquiry|
|R1732||Type A Allatostatin I||Inquiry|
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