(Arg22)-Stichodactyla helianthus Neurotoxin (ShK) incorporates an arginine substitution that modifies the electrostatic surface potential, influencing receptor binding. This neurotoxin acts as a potent inhibitor of voltage-gated potassium channels, and the modification enhances its specificity. Researchers employ this analog to study ion channel regulation and toxin-receptor interactions in neurophysiological systems.
1. TMEM16F and dynamins control expansive plasma membrane reservoirs
4. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry
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