Argipressin binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Argipressin is a selective V2 agonist.
CAT No: HB00115
CAS No:129979-57-3
Synonyms/Alias:[Arg8]Vasopressin TFA;129979-57-3;(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid;(ARG8)-VASOPRESSIN TRIFLUOROACETATE SALT;G85507;S-129979-57-3;(2S)-2-{[(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl]pyrrolidin-2-yl]formamido}-5-carbamimidamido-N-(carbamoylmethyl)pentanamide; trifluoroacetic acid;126828-97-5;
Argipressin Acetate is a synthetic peptide analog of the naturally occurring antidiuretic hormone vasopressin, featuring an acetylated form optimized for research and biochemical applications. As a nonapeptide, it plays a crucial role in the regulation of water homeostasis and vascular tone, making it highly relevant in studies exploring endocrine signaling, renal physiology, and vascular biology. Its well-characterized structure and receptor specificity provide a robust tool for dissecting mechanisms of peptide hormone action, receptor binding, and downstream signaling pathways. The compound's stability and functional mimicry of endogenous argipressin render it valuable for a range of experimental systems investigating neurohypophyseal peptide function.
Receptor Binding Studies: Argipressin Acetate serves as an essential ligand for in vitro and in vivo investigations of vasopressin receptor subtypes, particularly V1 and V2 receptors. By enabling precise modulation of these G protein-coupled receptors, the peptide facilitates detailed mapping of receptor pharmacology, ligand affinity, and downstream signaling cascades. Researchers utilize it to dissect the molecular determinants of receptor activation, antagonism, and desensitization, contributing to a deeper understanding of peptide-receptor interactions in physiological and pathophysiological contexts.
Signal Transduction Research: Due to its ability to activate canonical vasopressin signaling pathways, Argipressin Acetate is widely employed in studies aiming to elucidate the cellular and molecular mechanisms underlying water reabsorption, vasoconstriction, and smooth muscle contraction. Its use enables the assessment of second messenger systems, such as cyclic AMP and intracellular calcium flux, and the evaluation of kinase activation profiles. These insights are critical for advancing knowledge of hormonal regulation and intracellular communication in target tissues.
Peptide Structure-Activity Relationship Analysis: The defined sequence and modifications present in Argipressin Acetate make it a model substrate for structure-activity relationship (SAR) studies among neuropeptides. Researchers leverage its properties to probe the impact of amino acid substitutions, terminal modifications, and peptide backbone alterations on biological activity and receptor selectivity. Such investigations inform the rational design of novel peptide analogs with tailored functional characteristics for experimental and therapeutic exploration.
Vascular Physiology Models: The peptide is routinely incorporated into ex vivo and in vitro models to investigate mechanisms of vasoconstriction and vascular reactivity. By providing a controlled stimulus to vascular smooth muscle preparations, Argipressin Acetate enables quantification of contractile responses, assessment of endothelial function, and evaluation of pharmacological modulation by antagonists or enzyme inhibitors. These applications are instrumental in advancing vascular pharmacology and understanding the regulation of blood vessel tone.
Endocrine System Research: Argipressin Acetate is a preferred tool for probing the neuroendocrine regulation of fluid balance and osmoregulation in experimental systems. Its use in pituitary and renal cell models supports the study of hormone secretion dynamics, receptor-mediated feedback loops, and the integration of endocrine signals governing homeostasis. Such research provides foundational insights into hormonal control mechanisms and their disruption in disease models, facilitating the development of novel investigative strategies in endocrine physiology.
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