Argipressin binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Argipressin is a selective V2 agonist.
CAT No: HB00115
CAS No:129979-57-3
Synonyms/Alias:[Arg8]Vasopressin TFA;129979-57-3;(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid;(ARG8)-VASOPRESSIN TRIFLUOROACETATE SALT;G85507;S-129979-57-3;(2S)-2-{[(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl]pyrrolidin-2-yl]formamido}-5-carbamimidamido-N-(carbamoylmethyl)pentanamide; trifluoroacetic acid;126828-97-5;
Argipressin Acetate, also known as vasopressin or antidiuretic hormone (ADH) acetate, is a synthetic peptide analog that plays a critical role in water regulation and vascular tone modulation. As a potent nonapeptide, it mimics the physiological actions of endogenous vasopressin, binding to specific receptors in the body to elicit a range of biological effects. Its unique structure and stability make it a valuable tool in experimental research, enabling scientists to investigate the molecular pathways involved in osmoregulation, cardiovascular function, and neuroendocrine signaling. The acetate form enhances its solubility and handling in laboratory settings, making it suitable for diverse in vitro and in vivo applications. Researchers rely on Argipressin Acetate to dissect the intricate mechanisms of hormone action, receptor interaction, and signal transduction within various biological systems.
Water Homeostasis Research: Argipressin Acetate is extensively utilized in studies focused on water balance and osmoregulation. By acting on V2 receptors in renal collecting ducts, it promotes water reabsorption, allowing researchers to model and analyze the physiological responses to changes in plasma osmolality. This application is particularly valuable for elucidating the molecular underpinnings of water conservation and the hormonal regulation of kidney function under different experimental conditions.
Vascular Physiology Studies: Vasopressin acetate serves as an essential tool for examining vascular smooth muscle contraction and blood pressure regulation. Through its interaction with V1a receptors on vascular smooth muscle cells, it induces vasoconstriction, thereby modulating systemic vascular resistance. Scientists employ it to model hypertensive states, study the dynamics of vasoconstriction, and explore potential therapeutic targets for vascular disorders in preclinical research.
Cell Signaling Pathway Analysis: The peptide is instrumental in dissecting G protein-coupled receptor (GPCR) signaling cascades. Its well-characterized receptor interactions facilitate the study of downstream effectors such as phospholipase C, inositol trisphosphate, and calcium mobilization. Researchers use Argipressin Acetate to probe the specificity and kinetics of GPCR-mediated responses, contributing to a deeper understanding of intracellular communication and hormone-receptor dynamics.
Neuroendocrine Regulation Investigations: As a neuropeptide, vasopressin acetate is pivotal in exploring the regulation of neuroendocrine axes, particularly the hypothalamic-pituitary-adrenal (HPA) axis. By modulating the release of adrenocorticotropic hormone (ACTH) and influencing stress-related pathways, it provides a model for studying neuroendocrine integration and the feedback mechanisms governing hormone secretion in response to physiological and environmental stimuli.
Behavioral and Cognitive Research: Argipressin Acetate is also applied in neuroscience to investigate its effects on social behaviors, memory formation, and emotional regulation. Experimental models leverage its role as a neuromodulator to study the impact of vasopressinergic signaling on learning, aggression, pair bonding, and anxiety-like behaviors, thereby advancing the understanding of peptide hormones in central nervous system function.
Overall, Argipressin Acetate stands out as a multifaceted research reagent that supports a wide array of scientific inquiries spanning renal physiology, cardiovascular biology, cell signaling, neuroendocrinology, and behavioral neuroscience. Its versatility and robust pharmacological profile make it indispensable for unraveling complex physiological processes and for driving innovation in basic and translational research. As ongoing studies continue to uncover new roles and mechanisms, Argipressin Acetate remains a cornerstone peptide for advancing knowledge across multiple domains of life sciences.
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