Bam 12P is a short, designed peptide carrying a defined pattern of hydrophobic and polar residues for membrane and receptor-binding research. Sequence composition supports amphipathic helix formation and aggregation studies. Researchers analyze its structure in micelles and bilayer mimetics. Applications include antimicrobial-peptide modeling, folding-function correlations, and peptide-membrane interaction analysis.
CAT No: R2576
CAS No:75513-71-2
Synonyms/Alias:Bam-12P;75513-71-2;Bam 12P;L-Glutamic acid, N-(1-(N(2)-(N-(N-(N(2)-(N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-methionyl)-L-arginyl)-L-arginyl)-L-valyl)glycyl)-L-arginyl)-L-prolyl)-;Bovine adrenal medulla dodecapeptide;6,7-Arg-8-val-9-gly-10-arg-11-pro-12-glu-met-enkephalin;Enkephalin-met, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-;Met-enkephalin, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-;Methionine-enkephalin, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-;Enkephalin-met, arginyl(6,7)-valyl(8)-glycyl(9)-arginyl(10)-prolyl(11)-glu(12)-;MFCD00076689;EX-A7440;AKOS040744571;DA-71685;BAM-12P (H-L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Arg-L-Val-Gly-L-Arg-L-Pro-L-Glu-OH);(2S)-2-[[(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)- 2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl] amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl] amino]-5-(diaminomethylideneamino)pentanoyl];(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-(methylsulfanyl)butanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-3-methylbutanamido]acetamido}-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]formamido}pentanedioic acid;
Bam 12P is a synthetic peptide compound designed for advanced research applications in the field of cell signaling and molecular pharmacology. As a bioactive peptide, it is structurally characterized by a specific amino acid sequence that enables selective interaction with target proteins involved in regulatory pathways. Its functional relevance stems from its capacity to modulate intracellular signaling cascades, making it a valuable tool for dissecting complex biochemical networks. The versatility and specificity of Bam 12P have positioned it as a prominent reagent in studies aiming to elucidate the mechanisms underlying cellular communication, receptor activation, and downstream effectors within various biological systems.
Signal transduction research: Bam 12P is widely employed in studies investigating the mechanisms of G protein-coupled receptor (GPCR) signaling. By mimicking or inhibiting endogenous peptide ligands, it allows researchers to probe the activation, desensitization, and regulatory dynamics of GPCRs in vitro. Utilizing this peptide in cellular assays provides insights into receptor-ligand interactions, second messenger generation, and the modulation of signaling pathways that govern physiological responses. Such applications are instrumental in mapping the intricate web of intracellular communication and in identifying novel regulatory nodes within signaling networks.
Pharmacological profiling: In drug discovery and receptor pharmacology, Bam 12P serves as a reference ligand or functional modulator in high-throughput screening platforms. Its defined sequence and activity profile facilitate the characterization of receptor subtype selectivity, agonist or antagonist properties, and dose-response relationships. Researchers leverage these attributes to benchmark the efficacy and potency of new compounds, enabling more precise structure-activity relationship (SAR) studies and the identification of potential lead candidates for further optimization.
Peptide-receptor binding studies: The compound is frequently utilized in binding affinity assays to quantify and compare interactions between peptides and their cognate receptors. Through radioligand displacement, fluorescence polarization, or surface plasmon resonance techniques, Bam 12P assists in delineating binding kinetics, specificity, and allosteric modulation. These experiments are critical for understanding the molecular determinants of receptor recognition and for guiding the rational design of novel peptide analogs with improved functional properties.
Cellular functional assays: Bam 12P is incorporated into a variety of cell-based experimental systems to assess its effects on cellular processes such as calcium mobilization, kinase activation, and gene expression. By monitoring changes in cellular phenotypes in response to peptide stimulation or inhibition, researchers can unravel the downstream consequences of receptor engagement. These assays contribute to the broader understanding of how peptide-mediated signaling influences cell fate decisions, differentiation, and adaptive responses under physiological or experimental conditions.
Peptide structure-function analysis: The well-defined sequence of Bam 12P makes it an excellent model for exploring the relationship between peptide structure and biological activity. Through systematic substitution, truncation, or labeling studies, researchers can dissect the contribution of individual amino acid residues to receptor binding, signal initiation, and stability. Such investigations are vital for advancing knowledge of peptide engineering principles, optimizing bioactivity, and developing novel analogs with tailored functional profiles for research or industrial applications.
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