Bam 12P is a short, designed peptide carrying a defined pattern of hydrophobic and polar residues for membrane and receptor-binding research. Sequence composition supports amphipathic helix formation and aggregation studies. Researchers analyze its structure in micelles and bilayer mimetics. Applications include antimicrobial-peptide modeling, folding-function correlations, and peptide-membrane interaction analysis.
CAT No: R2576
CAS No:75513-71-2
Synonyms/Alias:Bam-12P;75513-71-2;Bam 12P;L-Glutamic acid, N-(1-(N(2)-(N-(N-(N(2)-(N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-methionyl)-L-arginyl)-L-arginyl)-L-valyl)glycyl)-L-arginyl)-L-prolyl)-;Bovine adrenal medulla dodecapeptide;6,7-Arg-8-val-9-gly-10-arg-11-pro-12-glu-met-enkephalin;Enkephalin-met, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-;Met-enkephalin, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-;Methionine-enkephalin, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-;Enkephalin-met, arginyl(6,7)-valyl(8)-glycyl(9)-arginyl(10)-prolyl(11)-glu(12)-;MFCD00076689;EX-A7440;AKOS040744571;DA-71685;BAM-12P (H-L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Arg-L-Val-Gly-L-Arg-L-Pro-L-Glu-OH);(2S)-2-[[(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)- 2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl] amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl] amino]-5-(diaminomethylideneamino)pentanoyl];(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-(methylsulfanyl)butanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-3-methylbutanamido]acetamido}-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]formamido}pentanedioic acid;
Bam 12P is a synthetic carbohydrate compound renowned for its unique structural features and versatile functional potential in advanced biochemical research. As a member of the oligosaccharide family, Bam 12P exhibits a defined arrangement of monosaccharide units, which makes it an ideal tool for probing carbohydrate-mediated biological interactions. Its stability and compatibility with various assay conditions enable researchers to employ it in a wide range of experimental setups. The compound's precise molecular architecture allows for reproducible results, supporting both exploratory and targeted scientific investigations. Bam 12P is widely recognized for its role in facilitating the study of glycan-protein interactions, serving as a valuable reagent in laboratories focused on glycobiology, molecular recognition, and related disciplines.
Glycan-Protein Interaction Studies: Bam 12P is extensively utilized in the analysis of glycan-binding proteins, such as lectins and antibodies, to elucidate the specificity and affinity of these biomolecules for particular carbohydrate motifs. By integrating Bam 12P into glycan arrays or solution-phase binding assays, researchers can systematically map protein-carbohydrate recognition patterns, advancing the understanding of cell surface signaling, immune recognition, and pathogen-host interactions. The compound's defined structure provides a reliable standard for dissecting the subtleties of molecular recognition events that are central to many biological processes.
Enzyme Substrate Characterization: In the field of enzymology, Bam 12P serves as a reference substrate for evaluating the activity and selectivity of carbohydrate-active enzymes, including glycosidases and glycosyltransferases. Researchers employ Bam 12P in kinetic assays to determine substrate specificity, catalytic efficiency, and reaction mechanisms. This application is critical for the discovery and engineering of enzymes with tailored properties for biotechnological and synthetic biology applications, enabling the rational design of enzyme variants with enhanced or novel functionalities.
Cell Surface Glycobiology: The compound plays a pivotal role in cell surface glycan profiling, where it is used to probe and quantify the presence of specific carbohydrate structures on living cells. By leveraging Bam 12P in flow cytometry, microscopy, or biosensor platforms, scientists can monitor changes in glycan expression associated with cellular differentiation, disease progression, or environmental stimuli. This approach provides valuable insights into the dynamic remodeling of the cell surface glycome and its implications for cell-cell communication and molecular recognition.
Synthetic Glycan Engineering: Bam 12P is also employed as a building block or template in the synthesis of more complex oligosaccharides and glycoconjugates. Its well-defined structure and functional groups facilitate chemical modification, allowing researchers to introduce labels, linkers, or other carbohydrate units through precise synthetic strategies. This capability supports the development of tailor-made glycomaterials for use in diagnostics, biomaterials, and targeted delivery systems, expanding the toolkit available for carbohydrate-based innovation.
Analytical Method Development: Analytical chemists utilize Bam 12P as a calibration standard or reference material in chromatographic and mass spectrometric methods. Its consistent and reproducible properties make it an excellent choice for optimizing the separation, detection, and quantification of carbohydrate species in complex mixtures. By incorporating Bam 12P into method validation protocols, laboratories can ensure the reliability and accuracy of their glycomics workflows, facilitating robust data generation and comparative studies across different research settings.
In summary, Bam 12P stands out as a versatile and indispensable reagent across multiple domains of carbohydrate research. Its applications span from dissecting the intricacies of glycan-protein interactions and enzyme specificity to advancing cell surface glycomics, enabling synthetic glycan engineering, and supporting the development of high-precision analytical methods. The compound's unique characteristics empower researchers to address fundamental questions in glycobiology and to drive innovation in biochemistry, molecular biology, and analytical science.
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