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Bax inhibitor peptide V5

BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet, and anti-cancer drug.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Bax inhibitor peptide V5(CAS 579492-81-2)

CAT No: R1852

CAS No:579492-81-2

Synonyms/Alias:Bax inhibitor peptide V5;579492-81-2;Val-Pro-Met-Leu-Lys;(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid;BIP-V5;BIP-V5;BAX Inhibiting Peptide V5;Bax inhibitor peptide V5?;HY-P0081;BAX Inhibiting Peptide V5; BIP-V5;AKOS024456777;CS-5509;DA-61502;D83676;

Chemical Name:(S)-6-amino-2-((Z)-((S)-2-((Z)-((S)-2-((Z)-(((S)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)(hydroxy)methylene)amino)-1-hydroxy-4-(methylthio)butylidene)amino)-1-hydroxy-4-methylpentylidene)amino)hexanoic acid

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C27H50N6O6S
M.W/Mr.
586.8
Sequence
One Letter Code:VPMLK
Three Letter Code:H-Val-Pro-Met-Leu-Lys-OH
Labeling Target
Apoptosis
Appearance
Crystalline solid
Purity
≥97% (HPLC)
Activity
Inhibitor
Areas of Interest
Cancer
Source#
Synthetic
Long-term Storage Conditions
≥29.35mg/mL in DMSO,insoluble in EtOH, ≥91.4 mg/mL in H2O
Shipping Condition
Evaluation sample solution : ship with blue ice; All other available size: ship with RT , or blue ice upon request
Solubility
-20 °C
InChI
InChI=1S/C27H50N6O6S/c1-16(2)15-20(24(35)31-19(27(38)39)9-6-7-12-28)32-23(34)18(11-14-40-5)30-25(36)21-10-8-13-33(21)26(37)22(29)17(3)4/h16-22H,6-15,28-29H2,1-5H3,(H,30,36)(H,31,35)(H,32,34)(H,38,39)/t18-,19-,20-,21-,22-/m0/s1
InChI Key
NHMUTADCTDDWPV-YFNVTMOMSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCSC)NC(=O)C1CCCN1C(=O)C(C(C)C)N
Isomeric SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N
BoilingPoint
N/A
References
Sawatzky DA, et al. The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. The American Journal of Pathology. 2006; 168(1):33-41.
Melting Point
N/A

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