Betiatide

Betiatide is a short regulatory peptide containing charged and hydrophobic residues that create a balanced conformational profile. The sequence supports exploration of reversible structural transitions, hydrogen bonding, and intermolecular interactions. Researchers use it in mapping ligand-recognition motifs and dynamic folding landscapes. Its compact design aids detailed structural analysis.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Betiatide(CAS 103725-47-9)

CAT No: R2273

CAS No:103725-47-9

Synonyms/Alias:Betiatide;103725-47-9;UNII-9NV2SR34P8;MP-600;S-benzoyl-MAG3;9NV2SR34P8;S-Benzoylmercaptoacetyltriglycine;DTXSID3048788;MP 600;DTXCID3028714;Betiatide (USAN);Glycine, N-(N-(N-((benzoylthio)acetyl)glycyl)glycyl);Glycine, N-(N-(N-((benzoylthio)acetyl)glycyl)glycyl)-;NCGC00182993-01;BETIATIDE [USAN];Thiobenzoic acid, S-ester with N-(N-(N-(mercaptoacetyl)glycyl)glycyl)glycine;N-(N-(N-(Mercaptoacetyl)glycyl)glycyl)glycine benzoate (ester);1,4,7,10-tetraoxo-1-phenyl-2-thia-5,8,11-triazatridecan-13-oic acid;betiatidum;Betiatida;Betiatide [USAN:INN:BAN];N-[N-[N-(Mercaptoacetyl)glycyl]glycyl]glycine benzoate (ester);2-[[2-[[2-[(2-benzoylsulfanylacetyl)amino]acetyl]amino]acetyl]amino]acetic acid;benzoylmercaptoacetylglycylglycylglycine;BETIATIDE [INN];BETIATIDE [WHO-DD];Technescan Tc 99m Mertiatide;SCHEMBL1055212;CHEMBL3183117;CHEBI:136015;VDPYMEBVIDZKMD-UHFFFAOYSA-N;Tox21_113265;HY-P10369;MFCD00868930;AKOS016340732;DB14082;SS-4620;CAS-103725-47-9;CS-1051684;N-[(benzoylthio)-acetyl]glycylglycyl-glycine;NS00070179;D03105;EN300-18567860;Q27272797;Kit for the Preparation of Technetium Tc99m Mertiatide;2-(2-{2-[2-(benzoylsulfanyl)acetamido]acetamido}acetamido)acetic acid;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C15H17N3O6S
M.W/Mr.
367.4
Sequence
One Letter Code:GGG

Betiatide is a synthetic carbohydrate-peptide conjugate that has gained significant attention in biochemical research due to its unique structural features and versatile functional properties. Characterized by the presence of both peptide and carbohydrate moieties, Betiatide exhibits enhanced solubility and bioactivity, making it an attractive molecule for a wide range of scientific investigations. Its hybrid nature allows for interactions with various biological targets, enabling researchers to explore novel mechanisms of action within cellular systems. The strategic combination of peptide and carbohydrate elements in Betiatide not only improves its stability in aqueous environments but also facilitates its recognition by specific enzymes and receptors, thus expanding its potential utility in experimental protocols. As a result, Betiatide stands out as a valuable tool for scientists seeking to probe complex biological processes and develop innovative research methodologies.

Glycobiology research: In the field of glycobiology, Betiatide serves as a model compound for studying carbohydrate-protein interactions and glycosylation pathways. Researchers utilize this molecule to investigate how glycan modifications influence protein folding, trafficking, and function. By incorporating Betiatide into in vitro assays, scientists can dissect the roles of specific carbohydrate structures in cellular recognition events, signal transduction, and immune responses. Its defined architecture makes it ideal for mapping binding sites on lectins and other glycan-binding proteins, thereby advancing the understanding of glycan-mediated communication in biological systems.

Enzymatic activity assays: Betiatide is frequently employed in the analysis of glycosidase and protease activities. Due to its dual peptide-carbohydrate structure, it acts as a versatile substrate for monitoring enzyme specificity and catalytic efficiency. Enzymologists can use Betiatide to screen for inhibitors or activators of enzymes involved in glycan processing or peptide cleavage. This application is particularly valuable for characterizing enzyme kinetics, elucidating substrate preferences, and optimizing assay conditions for high-throughput screening platforms.

Drug delivery research: The amphiphilic properties of Betiatide make it a promising candidate for the development of targeted drug delivery systems. Scientists explore its ability to form stable conjugates with therapeutic agents, enhancing their solubility, bioavailability, and cellular uptake. By leveraging the recognition capabilities of the carbohydrate moiety, Betiatide-based carriers can be engineered to selectively bind to cell surface receptors, facilitating site-specific delivery of drugs or imaging agents. This targeted approach holds potential for improving the efficacy and safety profiles of experimental therapeutics in preclinical studies.

Cell signaling studies: Betiatide is utilized to probe the effects of glycopeptide modifications on cell signaling pathways. Researchers introduce Betiatide into cultured cells to assess how changes in glycosylation patterns impact receptor activation, downstream signaling cascades, and gene expression. Its defined structure allows for systematic evaluation of structure-activity relationships, providing insights into the molecular mechanisms by which glycopeptides modulate cellular responses. This application supports the identification of key regulatory nodes and the development of molecular probes for dissecting signal transduction networks.

Analytical method development: In analytical chemistry, Betiatide is used as a standard or reference compound for the validation of chromatographic and mass spectrometric techniques. Its well-defined composition and physicochemical properties make it suitable for calibrating instruments, optimizing separation parameters, and establishing detection limits for glycopeptides. Analytical laboratories incorporate Betiatide into method development workflows to ensure accuracy, reproducibility, and sensitivity in the quantification of complex biomolecules. This role is essential for advancing the capabilities of bioanalytical platforms and supporting high-quality data generation in carbohydrate and peptide research.

Synthetic biology applications: The versatility of Betiatide extends to synthetic biology, where it is employed as a modular building block for the design of novel biomaterials and engineered proteins. Researchers can incorporate Betiatide into synthetic constructs to impart specific functional attributes, such as enhanced solubility, stability, or recognition by biological macromolecules. This application enables the creation of innovative scaffolds for tissue engineering, biosensing, and molecular assembly, contributing to the advancement of interdisciplinary research at the interface of chemistry, biology, and materials science. Through these diverse applications, Betiatide continues to play a pivotal role in expanding the frontiers of carbohydrate and peptide research, offering new opportunities for scientific discovery and technological innovation.

InChI
InChI=1S/C15H17N3O6S/c19-11(16-6-12(20)18-8-14(22)23)7-17-13(21)9-25-15(24)10-4-2-1-3-5-10/h1-5H,6-9H2,(H,16,19)(H,17,21)(H,18,20)(H,22,23)
InChI Key
VDPYMEBVIDZKMD-UHFFFAOYSA-N

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