This is a 21 amino acid peptide derived from Buforin I peptide that is isolated from the Asian toad Bufo gargarizans,also referred to as Buforin II. It has been shown to possess anti-microbial activity by penetrating bacteria and inhibiting cellular functions. In comparison to magainin 2, this peptide binds DNA and RNA from E.coli with a much greater affinity. It is also considered a cell-delivery peptide and has been shown to deliver SiRNAs into cells followed by effective mRNA degradation.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
M.W/Mr. | 2434.9 |
Sequence | H-Thr-Arg-Ser-Ser-Arg-Ala-Gly-Leu-Gln-Phe-Pro-Val-Gly-Arg-Val-His-Arg-Leu-Leu-Arg-Lys-OH |
Long-term Storage Conditions | Soluble in pure water. Avoid repeated freezing and thawing. |
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