C-Reactive Protein (CRP) 201-206 is the 201-206 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.
C-Reactive Protein (CRP) 201-206 is a synthetic peptide fragment derived from the human acute-phase protein C-reactive protein, specifically corresponding to amino acid residues 201 through 206. As a peptide compound, it serves as a valuable molecular tool for investigating the structure, function, and biological roles of CRP in inflammation and immune system regulation. The sequence offers a focused approach for researchers seeking to dissect epitope-specific interactions, map functional domains, or develop peptide-based reagents relevant to CRP's biochemical activity. Its defined structure enables precise experimental design in both fundamental and applied studies of inflammatory processes, immune signaling, and biomarker research.
Epitope Mapping: The 201-206 fragment is commonly utilized in epitope mapping studies to identify and characterize antibody binding sites within the CRP molecule. By employing this peptide in immunoassays or affinity purification protocols, researchers can delineate the specific regions of CRP recognized by monoclonal or polyclonal antibodies. This approach aids in the development of highly specific immunodetection reagents, supports the refinement of diagnostic assays, and enhances the understanding of immune recognition mechanisms associated with CRP.
Antigenicity Assessment: Synthetic peptides corresponding to defined CRP sequences, such as residues 201-206, are instrumental in evaluating antigenic determinants that contribute to immune system recognition. Use of this peptide in enzyme-linked immunosorbent assays (ELISA), Western blotting, or other immunological assays enables the assessment of cross-reactivity, immunodominance, and specificity of antibody responses. Such studies are critical for optimizing assay selectivity and for advancing the design of CRP-targeted research tools.
Protein-Protein Interaction Studies: The CRP 201-206 peptide serves as a model substrate for probing protein-protein interactions involving CRP and its physiological partners. By incorporating the peptide into binding assays or competition experiments, scientists can investigate the molecular determinants of CRP's interactions with ligands such as complement components, receptors, or other acute-phase proteins. These studies provide mechanistic insights into the functional domains of CRP and their relevance to inflammation and host defense.
Peptide-Based Assay Development: The defined sequence of the 201-206 region enables its use in the development and validation of peptide-based analytical assays. Researchers can employ this peptide as a standard or control in quantitative immunoassays, facilitating the calibration and benchmarking of CRP detection platforms. Its application in assay development supports the generation of robust, reproducible, and sensitive methodologies for the study of CRP dynamics in biological samples.
Structure-Function Analysis: Utilization of the 201-206 peptide allows for targeted structure-function analysis of CRP. By studying this segment in isolation or in the context of peptide analogs, researchers can elucidate the contribution of specific amino acid residues to the overall conformation, stability, and biological activity of CRP. Such investigations are essential for understanding how discrete regions of the protein influence its physiological roles, and for informing the design of novel CRP modulators or inhibitors for research use.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More