Cargutocin is a synthetic oxytocin analogue predominantly used in the biomedical industry as a labor-inducing agent during childbirth. It helps stimulate uterine contractions, thereby easing delivery.
CAT No: R1976
CAS No:33605-67-3
Chemical Name:(2S,5S,8S,11S,14S)-11-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-8-(3-amino-3-oxopropyl)-5-[(2S)-butan-2-yl]-2-[(4-hydroxyphenyl)methyl]-3,6,9,12,20-pentaoxo-1,4,7,10,13-pentazacycloicosane-14-carboxamide
Cargutocin is a synthetic peptide analog of oxytocin, designed to mimic and enhance the biological activity of the natural hormone while exhibiting improved metabolic stability. As a nonapeptide, it features structural modifications that confer resistance to enzymatic degradation, making it a valuable tool for advanced biochemical and pharmacological research. Its capacity to selectively bind and activate oxytocin receptors has positioned it as a critical reagent for studies investigating peptide-receptor interactions, signal transduction pathways, and the physiological roles of oxytocinergic systems. Researchers leverage its unique properties to dissect the mechanisms underlying peptide hormone action and to develop new methodologies for peptide-based investigations.
Receptor binding studies: Cargutocin serves as a robust ligand in receptor binding assays, allowing scientists to characterize the specificity, affinity, and kinetics of oxytocin receptors across various biological systems. The enhanced stability of this analog makes it particularly suitable for prolonged or complex in vitro experiments, where rapid degradation of native oxytocin would otherwise limit experimental accuracy. Through competitive binding and displacement assays, it enables detailed mapping of receptor-ligand interactions, contributing to a deeper understanding of receptor pharmacology and the structural determinants of peptide recognition.
Signal transduction research: The peptide's ability to selectively activate oxytocin receptors provides a reliable means to investigate downstream signaling pathways, such as G protein-coupled receptor (GPCR) cascades, second messenger production, and calcium mobilization. By employing cargutocin in cell-based assays, researchers can dissect the molecular events initiated upon receptor activation, elucidate the modulation of intracellular signaling networks, and differentiate the functional outcomes of oxytocin analogs versus the endogenous hormone. These insights are critical for the rational design of novel peptide modulators and for advancing the field of peptide hormone signaling.
Peptide structure-activity relationship (SAR) analysis: Cargutocin's defined sequence and modifications make it an exemplary model for SAR studies, where systematic comparisons between analogs reveal the impact of specific amino acid substitutions on biological activity. By integrating cargutocin into SAR workflows, scientists can probe the structural features essential for receptor binding, agonist potency, and metabolic stability. Such investigations inform the design of next-generation peptide therapeutics and provide foundational knowledge for the development of customized analogs with tailored properties.
Peptide synthesis validation: Due to its well-characterized sequence and established bioactivity, cargutocin is frequently employed as a reference standard in peptide synthesis and analytical laboratories. Its use in high-performance liquid chromatography (HPLC), mass spectrometry, and purity assessment protocols assists researchers in validating synthetic methodologies, optimizing purification strategies, and benchmarking analytical performance. This role supports quality assurance in peptide production and facilitates the development of robust analytical workflows for complex peptide compounds.
Functional studies of oxytocinergic systems: As a stable oxytocin analog, cargutocin is instrumental in probing the physiological and biochemical roles of oxytocin signaling in diverse experimental models. Its application extends to investigations of receptor distribution, tissue-specific responses, and feedback mechanisms within neuroendocrine and peripheral systems. By providing a reliable and consistent tool for modulating oxytocin pathways, cargutocin enables researchers to unravel the intricacies of peptide hormone function and to explore the broader implications of oxytocinergic regulation in cellular and systemic contexts.
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