Caspase Inhibitor I

Name: Caspase Inhibitor I
Brand: Creative Peptides
SKU: R1807
Availability: MadeToOrder

Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1.

Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

CAT No: R1807

CAS No: 187389-52-2

Synonyms/Alias: 187389-52-2;Z-VAD(OMe)-FMK;Z-Val-Ala-Asp(OMe)-FMK;pan-caspase inhibitor;C22H30FN3O7;ZVAD-FMK;5-Bromo-2 -deoxyuridine;Z-VAD (OMe)-FMK;Z-Val-Ala-Asp(OMe)-fluoromethyl ketone;Z-Val-Ala-Asp(OMe)-CH2F;methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate;Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone;z-Val-Ala-Asp(OMe)-fluoromethylketone;methyl (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate;methyl 5-fluoro-3-[2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoylamino]-4-oxopentanoate;Z-Val-Ala-Asp(OCH3)-fluoromethylketone;L-alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-;METHYL (3S)-3-[(2S)-2-[(2S)-2-{[(BENZYLOXY)CARBONYL]AMINO}-3-METHYLBUTANAMIDO]PROPANAMIDO]-5-FLUORO-4-OXOPENTANOATE;benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone;N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone;MFCD02684037;Bio2_000471;Z-VAD(OMe)-FMK?;Z-VAD-(OMe)-FMK;Probes1_000501;CBiol_001923;BSPBio_001262;KBioGR_000602;KBioSS_000602;Caspase-1 Inhibitor Z-Val-Ala-DL-Asp-fluoromethylketone;CHEMBL1213366;SCHEMBL15012737;Z-Val-Ala-Asp(OCH3)-CH2F;KBio2_000602;KBio2_003170;KBio2_005738;KBio3_001063;KBio3_001064;DTXSID40420586;CHEBI:137045;Bio1_000209;Bio1_000698;Bio1_001187;Bio2_000951;HMS1362P03;HMS1792P03;HMS1990P03;HMS3403P03;EX-A2192;HB1285;HB1319;Z-L-Val-L-Ala-L-Asp(OMe)-CH2F;AKOS024456966;z-Val-Ala-Asp(OMe) fluoromethylketone;CCG-207882;CS-3153;IDI1_002226;z-Val-Ala-Asp(OMe)-fluoromethyl-ketone;Cbz-Val-Ala-Asp(OMe)-fluoromethylketone;NCGC00163487-01;NCGC00163487-02;AS-74918;Cbz-Val-Ala-Asp(OMe)-fluoromethyl ketone;HY-16658;Z-Val-Ala-Asp(OCH3)-fluoromethyl ketone;z-Val-Ala-Asp(O-methyl)-fluoromethylketone;SW219162-1;Caspase Inhibitor I - CAS 187389-52-2;Z-VAD(OMe)-FMK; Z-Val-Ala-Asp(OMe)-FMK;benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone;benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethylketone;benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethylketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethyl ketone;benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethylketone;N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl) fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethylketone;(5S,8S,11S)-Methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]- (9CI);N-[(benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]-L-alaninamide;

Quick Inquiry Custom Peptide Synthesis

Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C22H30FN3O7
M.W/Mr.	467.5
Sequence	One Letter Code:VAX Three Letter Code:Cbz-Val-Ala-Asp(OMe)-CH2F
Labeling Target	Pan-caspase
Application	Z-VAD-FMK is an irreversible, cell-permeable, broad-spectrum caspase inhibitor.
Appearance	White solid
Purity	>98.0%
Activity	Inhibitor
Areas of Interest	Cancer

Source#	Synthetic
Long-term Storage Conditions	Soluble in DMSO
Shipping Condition	Room temperature in continental US; may vary elsewhere.
Solubility	-20 °C
InChI	InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChI Key	MIFGOLAMNLSLGH-QOKNQOGYSA-N
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
BoilingPoint	732.4±60.0 °C at 760 mmHg
Melting Point	N/A

1. High fat diet and GLP-1 drugs induce pancreatic injury in mice

2. Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation

3. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

4. Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L

5. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die

Write a review Ask a question

Featured Recommendations

Related Screening Libraries:

Peptide Drug Gene Construction and Expression Platform Peptide Screening Services High-throughput Screening Peptide Tools AI-based Peptide Drug Discovery and Structure Analysis Platform

Related Small Molecules:

Histrelin Nesiritide Secretin (28-54), human Leuprolide Goserelin CEF1, Influenza Matrix Protein M1 58-66 Secretin (33-59), rat

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at info@creative-peptides.com. We will endeavor to provide highly satisfying products and services.

Featured Services

Terlipressin Acetate

Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.

Inquiry
Deslorelin

Deslorelin is a gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen). It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland.

Inquiry
Thymopentin Acetate

Thymopentin, also known as TP-5, is a synthetic derivative of thymopoietin, a thymic hormone, and has immunoregulatory properties. Thymopentin interacts with T cells, reduces endocrine and behavioral responses to experimental stress. It is also found to increase the number of cells undergoing apoptosis in irradiated cells and selectively bind to apoptotic cells.

Inquiry
DOTA-cyclo(RGDfK) acetate

Inquiry
Somatostatin

Somatostatin is a tetradecapeptide which can suppress the growth hormone (GH) secretion and control the pituitary hormone secretion in human CNS.

Inquiry
Argipressin

Vasopressin, also known as arginine vasopressin (AVP), antidiuretic hormone (ADH), or argipressin, is a neurohypophysial hormone found in most mammals. Its two primary functions are to retain water in the body and to constrict blood vessels.

Inquiry
Carbetocin

Carbetocin is a long-acting synthetic agonist analogue of human oxytocin, with antihemorrhagic and uterotonic activities. Upon administration, carbetocin targets, binds to and activates peripheral oxytocin receptors that are present on the smooth musculature of the uterus. This causes uterus contractions and prevents excessive bleeding after childbirth, particularly following Cesarean section, and may be used to decrease blood loss during hysteroscopic myomectomy.

Inquiry
Alarelin acetate

Alarelin acetate is a synthetic LH-RH agonist, and stimulates the release of FSH and LH from the pituitary gland. It is known for its induction of ovulation and used to treat endmometriosis.

Inquiry
Buserelin Acetate

Buserelin Acetate is an agonist of gonadotropin-releasing hormone receptor(GnRHR). Buserelin is a synthetic luteinizing hormone–releasing hormone (LHRH) analog.

Inquiry
Icatibant

Icatibant (Firazyr) is a synthetic peptidomimetic drug consisting of ten amino acids, and acts as an effective and specific antagonist of bradykinin B2 receptors. It has been approved in the EU for use in hereditary angioedema, and is under investigation for a number of other conditions in which bradykinin is thought to play a significant role.

Inquiry