Name: Caspase Inhibitor I
Brand: Creative Peptides
SKU: R1807
Availability: MadeToOrder

Specification Technical Data Publications Customer reviews and Q&A

Synonyms/Alias	187389-52-2;Z-VAD(OMe)-FMK;Z-Val-Ala-Asp(OMe)-FMK;pan-caspase inhibitor;C22H30FN3O7;ZVAD-FMK;5-Bromo-2 -deoxyuridine;Z-VAD (OMe)-FMK;Z-Val-Ala-Asp(OMe)-fluoromethyl ketone;Z-Val-Ala-Asp(OMe)-CH2F;methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate;Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone;z-Val-Ala-Asp(OMe)-fluoromethylketone;methyl (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate;methyl 5-fluoro-3-[2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoylamino]-4-oxopentanoate;Z-Val-Ala-Asp(OCH3)-fluoromethylketone;L-alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-;METHYL (3S)-3-[(2S)-2-[(2S)-2-{[(BENZYLOXY)CARBONYL]AMINO}-3-METHYLBUTANAMIDO]PROPANAMIDO]-5-FLUORO-4-OXOPENTANOATE;benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone;N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone;MFCD02684037;Bio2_000471;Z-VAD(OMe)-FMK?;Z-VAD-(OMe)-FMK;Probes1_000501;CBiol_001923;BSPBio_001262;KBioGR_000602;KBioSS_000602;Caspase-1 Inhibitor Z-Val-Ala-DL-Asp-fluoromethylketone;CHEMBL1213366;SCHEMBL15012737;Z-Val-Ala-Asp(OCH3)-CH2F;KBio2_000602;KBio2_003170;KBio2_005738;KBio3_001063;KBio3_001064;DTXSID40420586;CHEBI:137045;Bio1_000209;Bio1_000698;Bio1_001187;Bio2_000951;HMS1362P03;HMS1792P03;HMS1990P03;HMS3403P03;EX-A2192;HB1285;HB1319;Z-L-Val-L-Ala-L-Asp(OMe)-CH2F;AKOS024456966;z-Val-Ala-Asp(OMe) fluoromethylketone;CCG-207882;CS-3153;IDI1_002226;z-Val-Ala-Asp(OMe)-fluoromethyl-ketone;Cbz-Val-Ala-Asp(OMe)-fluoromethylketone;NCGC00163487-01;NCGC00163487-02;AS-74918;Cbz-Val-Ala-Asp(OMe)-fluoromethyl ketone;HY-16658;Z-Val-Ala-Asp(OCH3)-fluoromethyl ketone;z-Val-Ala-Asp(O-methyl)-fluoromethylketone;SW219162-1;Caspase Inhibitor I - CAS 187389-52-2;Z-VAD(OMe)-FMK; Z-Val-Ala-Asp(OMe)-FMK;benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone;benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethylketone;benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethylketone;N-benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethyl ketone;benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethylketone;N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl) fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethyl ketone;N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethylketone;(5S,8S,11S)-Methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]- (9CI);N-[(benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]-L-alaninamide;
M.F/Formula	C22H30FN3O7
M.W/Mr.	467.5
Sequence	One Letter Code:VAX Three Letter Code:Cbz-Val-Ala-Asp(OMe)-CH2F
Labeling Target	Pan-caspase
Application	Z-VAD-FMK is an irreversible, cell-permeable, broad-spectrum caspase inhibitor.
Appearance	White solid
Purity	>98.0%
Activity	Inhibitor
Areas of Interest	Cancer

Source#	Synthetic
Long-term Storage Conditions	Soluble in DMSO
Shipping Condition	Room temperature in continental US; may vary elsewhere.
Solubility	-20 °C
InChI	InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChI Key	MIFGOLAMNLSLGH-QOKNQOGYSA-N
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
BoilingPoint	732.4±60.0 °C at 760 mmHg
Melting Point	N/A

1. Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells

2. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment

3. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

4. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

5. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy

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Caspase Inhibitor I

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