Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.
|Sequence||One Letter Code: RGDFV|
|Biological Activity||Potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.|
|Long-term Storage Conditions||Soluble to 10 mg/ml in water||Shipping Condition||Room temperature in continental US; may vary elsewhere.|
|CAT#||Product Name||M.W||Molecular Formula||Inquiry|
|R04019||RGD-targeted Proapoptotic Peptide||Inquiry|
|R04001||Integrin Binding Peptide||Inquiry|
1. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes
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