Cilengitide

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#	C5501
Chemical Structure
Synonyms/Alias	Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
M.F/Formula	C27H40N8O7
M.W/Mr.	588.66
Sequence	One Letter Code: RGDFV
Biological Activity	Potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Long-term Storage Conditions	Soluble to 10 mg/ml in water
Shipping Condition	Room temperature in continental US; may vary elsewhere.

CAT#	Product Name	M.W	Molecular Formula	Inquiry
R04021	Ac-Asp-Arg-Leu-Asp-Ser-OH			Inquiry
R04019	RGD-targeted Proapoptotic Peptide			Inquiry
R04034	Galacto-RGD			Inquiry
R04028	Cyclo(-Arg-Gly-Asp-D-Phe-Cys)			Inquiry
R04001	Integrin Binding Peptide			Inquiry

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