CMX-2043 is a promising biomedical product that functions as a potential therapeutic agent for cardiovascular diseases. It displays beneficial effects in treating heart failure, cardiac hypertrophy, and ischemic heart disease.
CAT No: R2008
CAS No:910627-26-8
Synonyms/Alias:CMX-2043;(R)-Lip-L-glu-L-ala-OH;910627-26-8;Lip-ea;R-lip-ea-oh;83V80O4XY1;R-Lipoic acid-L-glutamate-L-alanine;UNII-83V80O4XY1;L-Alanine, N-(5-(3R)-1,2-dithiolan-3-yl-1-oxopentyl)-L-alpha-glutamyl-;alpha-N-((R )-1,2-Dithiolane-3-pentanoyl)-L-glutamyl-L-alanine;L-ALANINE, N-(5-(3R)-1,2-DITHIOLAN-3-YL-1-OXOPENTYL)-L-.ALPHA.-GLUTAMYL-;(4S)-4-(5-((3R)-DITHIOLAN-3-YL)PENTANOYLAMINO)-5-(((1S)-2-HYDROXY-1-METHYL-2-OXO-ETHYL)AMINO)-5-OXO-PENTANOIC ACID;(4S)-5-[[(1S)-1-carboxyethyl]amino]-4-[5-[(3R)-dithiolan-3-yl]pentanoylamino]-5-oxopentanoic acid;(4S)-4-(((1S)-1-carboxyethyl)carbamoyl)-4-(5-((3R)-1,2-dithiolan-3-yl)pentanamido)butanoic acid;(4S)-4-{[(1S)-1-carboxyethyl]carbamoyl}-4-{5-[(3R)-1,2-dithiolan-3-yl]pentanamido}butanoic acid;SCHEMBL9282164;CHEMBL3099551;AKOS040748162;DB12795;DA-72298;MS-26973;HY-119152;CS-0069067;NS00072095;Q27269454;.ALPHA.-N-((R )-1,2-DITHIOLANE-3-PENTANOYL)-L-GLUTAMYL-L-ALANINE;.ALPHA.-N-((R)-1,2-DITHIOLANE-3-PENTANOYL)-L-GLUTAMYL-L-ALANINE;ALPHA-N-((R)-1,2-DITHIOLANE-3-PENTANOYL)-L-GLUTAMYL-L-ALANINE;
Chemical Name:(4S)-5-[[(1S)-1-carboxyethyl]amino]-4-[5-[(3R)-dithiolan-3-yl]pentanoylamino]-5-oxopentanoic acid
CMX-2043 is a synthetic small molecule belonging to the class of alpha-lipoic acid analogs, recognized for its redox-modulating properties and antioxidant activity in biochemical contexts. Structurally distinct from naturally occurring lipoic acid, it has been engineered to enhance metabolic stability while retaining the ability to interact with key cellular redox systems. Its unique chemical framework supports research into oxidative stress, mitochondrial function, and cellular protection mechanisms, making it a valuable tool for investigators probing the molecular basis of redox biology and related signaling pathways.
Redox Biology Research: CMX-2043 serves as a robust probe in studies focused on cellular redox regulation and oxidative stress. Its capacity to modulate thiol-disulfide exchange reactions allows researchers to investigate the dynamics of redox-sensitive proteins and enzymes under various experimental conditions. By acting as a redox-active agent, it facilitates the elucidation of mechanisms governing cellular responses to oxidative insults, providing insight into the role of redox balance in cell viability, signaling, and adaptation.
Mitochondrial Function Analysis: Utilization of this lipoic acid analog is particularly relevant in experiments designed to assess mitochondrial bioenergetics and integrity. Its structural features enable it to participate in the mitochondrial antioxidant defense system, supporting studies on mitochondrial membrane potential, electron transport chain efficiency, and ATP synthesis. Researchers employ CMX-2043 to dissect the interplay between mitochondrial oxidative stress and cellular energy metabolism, contributing to a deeper understanding of mitochondrial pathophysiology.
Neuroprotection Mechanism Studies: The compound is frequently used in in vitro models to explore mechanisms of neuronal resilience under oxidative or metabolic stress. By modulating redox homeostasis, it provides a means to investigate the cellular processes that underlie neuronal protection and survival. These studies are instrumental in mapping the molecular pathways that contribute to neurodegenerative processes and synaptic function, allowing for the identification of potential molecular targets involved in maintaining neuronal health.
Cellular Signaling Pathway Investigation: CMX-2043 is applied in research aimed at delineating the influence of redox status on intracellular signaling cascades. Its ability to alter the cellular redox environment makes it a useful agent for probing the regulation of transcription factors, kinases, and other signaling molecules sensitive to oxidative modification. Through such studies, scientists can characterize the impact of redox modulation on gene expression, cell cycle progression, and apoptotic pathways.
Drug Discovery and Screening: In the context of early-stage drug discovery, this compound is leveraged as a reference tool or comparator in high-throughput screening assays targeting redox-active molecules. Its defined mechanism of action and well-characterized biochemical profile enable its use in validating assay systems, benchmarking the activity of novel small molecules, and supporting the identification of new modulators of oxidative stress and mitochondrial dysfunction. These applications are integral to the development of next-generation research tools and the advancement of redox-targeted compound libraries.
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