Crustacean Cardioactive Peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardioactive Peptide (CCAP) also modulates the neuronal activity in other arthropods.
CAT No: R1309
CAS No:309247-84-5
Synonyms/Alias:Crustacean Cardioactive Peptide CCAP;309247-84-5;DA-72406;MS-31791;F85543;(2R)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-4-oxo-2-[[(2R)-2-[[(2S)-3-phenyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-sulfanylpropanoyl]amino]butanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-sulfanylpropanoic acid;
Crustacean Cardioactive Peptide CCAP is a neuropeptide originally identified in crustaceans, where it plays a pivotal role in modulating cardiac activity and various aspects of neuromuscular physiology. As a member of the broader family of cardioactive peptides, CCAP is characterized by its conserved sequence and functional versatility in invertebrate species. Its ability to influence rhythmic physiological processes, particularly within the nervous and circulatory systems, has established CCAP as a valuable tool for researchers investigating neuropeptide signaling, receptor interactions, and the evolutionary conservation of peptide function. The compound's well-defined structure and biological activity render it highly relevant for studies in comparative physiology, neurobiology, and bioactive peptide research.
Neuropeptide signaling research: CCAP is widely utilized in the study of neuropeptide signaling pathways within invertebrates, especially crustaceans and insects. Researchers employ this peptide to probe the molecular mechanisms underlying neurotransmission, synaptic modulation, and the regulation of rhythmic behaviors. By applying CCAP to isolated nervous tissues or in vivo models, scientists can elucidate receptor specificity, downstream signaling cascades, and the integration of neuropeptide signals within complex neural circuits, advancing the understanding of how neuropeptides coordinate physiological responses.
Cardiac physiology studies: The peptide's original identification as a modulator of cardiac function makes it a central reagent in investigations of invertebrate heart physiology. Experimental application of CCAP enables detailed analysis of its chronotropic and inotropic effects on isolated heart preparations, providing insights into the ionic mechanisms and second messenger systems that govern cardiac rhythm and contractility. Such studies are instrumental in uncovering the evolutionary origins of cardiac regulation and identifying potential analogs in other taxa.
Comparative endocrinology: CCAP serves as a model peptide for comparative endocrinology, allowing researchers to explore the conservation and divergence of peptide hormone systems across diverse invertebrate lineages. By analyzing the distribution, expression patterns, and functional effects of CCAP in different species, scientists gain a deeper appreciation for the evolutionary pressures shaping neuropeptide families and their physiological roles. This comparative approach aids in mapping the molecular evolution of peptide hormones and their receptors.
Peptide-receptor interaction assays: The well-characterized sequence and receptor specificity of CCAP make it an ideal ligand for in vitro receptor binding and functional assays. Researchers use synthetic CCAP to identify and characterize its cognate G protein-coupled receptors (GPCRs) in heterologous expression systems or native tissues. These studies facilitate structure-activity relationship analyses, receptor pharmacology investigations, and the screening of potential modulators or antagonists, thereby supporting the development of novel tools for neuropeptide research.
Peptide synthesis and analytical validation: Synthetic CCAP is frequently employed as a reference standard in peptide synthesis workflows and analytical validation protocols. Its defined structure and bioactivity make it suitable for calibrating mass spectrometry, high-performance liquid chromatography (HPLC), and other analytical techniques used in peptide chemistry. Utilizing CCAP as a benchmark aids in optimizing synthetic strategies, verifying peptide purity, and ensuring the reliability of analytical methods, which is essential for the broader field of bioactive peptide research.
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