Cyclo(-Pro-Thr) is a diketopiperazine formed by cyclization of proline and threonine, generating a rigid heterocycle with defined stereochemistry. The structure encourages β-turn mimicry and reduces backbone flexibility. Researchers use it to explore conformational constraints, peptide stabilization, and ligand-design principles. Its compact ring system supports detailed structural and mechanistic studies.
CAT No: R2280
CAS No:227777-31-3
Synonyms/Alias:Cyclo(-Pro-Thr);227777-31-3;Cyclo(Pro-Thr);(3S,8aS)-3-[(1R)-1-hydroxyethyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aS)-Hexahydro-3-[(1R)-1-hydroxyethyl]pyrrolo[1,2-a]pyrazine-1,4-dione;MFCD05663455;HY-P5050;(3S,8aS)-3-((R)-1-hydroxyethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;AKOS006293957;DA-62585;FC108331;CS-0675916;
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