This is a peptide corresponds to the protein transduction domain of the TAT protein and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group and is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. This is synthesized with C(Npys) at the N-terminus for applications requiring specific conjugation reactions and has a fluorophore labeled with FAM having Abs/Em=494/518 nm. This kind of modification has been used to render this peptide as a cell penetrating and carrier peptide applicable in conjugation studies.
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IND and NDA support Drug master files (DMF) filing
M.W/Mr. | 2302.7 |
Sequence | Cys(Npys) -Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys(FAM)-NH2 |
Long-term Storage Conditions | Soluble in water for a solution up to 2 mg/ml, otherwise acetonitrile is recommend. Avoid repeated freezing and thawing. |
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