Cys(Npys)-TAT (47-57), FAM-labeled

Name: Cys(Npys)-TAT (47-57), FAM-labeled
Brand: Creative Peptides
SKU: GR1227
Availability: MadeToOrder

This is a peptide corresponds to the protein transduction domain of the TAT protein and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group and is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. This is synthesized with C(Npys) at the N-terminus for applications requiring specific conjugation reactions and has a fluorophore labeled with FAM having Abs/Em=494/518 nm. This kind of modification has been used to render this peptide as a cell penetrating and carrier peptide applicable in conjugation studies.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: GR1227

Custom Peptide Synthesis

cGMP Peptide

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.W/Mr.

2302.7

Sequence

Cys(Npys) -Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys(FAM)-NH2

Long-term Storage Conditions

Soluble in water for a solution up to 2 mg/ml, otherwise acetonitrile is recommend. Avoid repeated freezing and thawing.

1. High fat diet and GLP-1 drugs induce pancreatic injury in mice

2. GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats

3. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

4. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

5. Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line

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