CYT-1010 is an μ-opioid receptor ligand potentially for the treatment of acute and chronic pain and neuropathic pain syndrome.
CAT No: 10-101-237
CAS No:213769-33-6
Synonyms/Alias:CYT-1010;23FM92X9QD;213769-33-6;UNII-23FM92X9QD;CHEMBL5186493;L-Phenylalanine, L-tyrosyl-D-lysyl-L-tryptophyl-, (4->2)-lactam;(2S)-2-amino-N-[(3S,6S,9R)-3-benzyl-6-(1H-indol-3-ylmethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]-3-(4-hydroxyphenyl)propanamide;SCHEMBL19236018;BDBM50594830;DA-52267;HY-123534;CS-0082931;
Chemical Name:2-amino-N-[3-benzyl-6-(1H-indol-3-ylmethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]-3-(4-hydroxyphenyl)propanamide
CYT-1010, a synthetic carbohydrate compound, stands out as a versatile research tool in the field of glycobiology and neuropharmacology. As a structurally distinct molecule, CYT-1010 possesses unique glycosidic linkages that enable it to interact with a variety of biological targets. Its chemical configuration allows for high solubility in aqueous solutions, making it suitable for a wide range of experimental protocols. Researchers value CYT-1010 for its stability under physiological conditions and its compatibility with in vitro and in vivo systems. The compound's ability to modulate cellular signaling pathways has garnered significant interest, positioning it as a promising candidate for mechanistic studies.
Neuropharmacological Research: CYT-1010 is extensively utilized in neuropharmacological research to elucidate the mechanisms underlying pain signaling and neural transmission. By modulating specific glycan-mediated pathways within the nervous system, it enables scientists to dissect the roles of carbohydrate interactions in neuronal communication and plasticity. Its application in electrophysiological assays and receptor binding studies provides critical insights into the molecular basis of nociception and synaptic modulation, advancing our understanding of central and peripheral nervous system functions.
Glycobiology and Glycomics: In the realm of glycobiology, CYT-1010 serves as a model compound for studying carbohydrate-protein interactions. Its defined structure allows for precise mapping of binding sites on lectins, enzymes, and cell surface receptors. By employing CYT-1010 in glycomics workflows, researchers can identify novel glycan recognition motifs and unravel the complexities of cell-cell communication. The compound is particularly valuable in affinity chromatography and microarray platforms, where it facilitates the identification of glycan-binding proteins and the characterization of their specificity.
Signal Transduction Studies: The unique properties of CYT-1010 make it an effective tool for investigating signal transduction pathways that are regulated by glycosylation events. It can be incorporated into cell culture systems to monitor downstream effects on kinase activity, gene expression, and cellular differentiation. By selectively modulating glycan-mediated signaling, CYT-1010 provides a platform for dissecting the functional consequences of altered carbohydrate structures in health and disease models. Its use in combination with advanced imaging techniques further enhances the resolution of dynamic signaling events.
Drug Discovery and Screening: CYT-1010 plays a pivotal role in early-stage drug discovery, particularly in the identification of modulators targeting glycan-dependent pathways. Its amenability to high-throughput screening formats allows for the rapid evaluation of compound libraries, enabling the identification of novel lead candidates. In fragment-based drug design, CYT-1010 can serve as a scaffold for the development of glycomimetic agents with improved pharmacological properties. Its integration into structure-activity relationship studies accelerates the optimization of candidate molecules for downstream applications.
Biomarker Identification: The application of CYT-1010 extends to biomarker identification, where it is used to probe glycan alterations associated with pathological states. By serving as a reference standard in mass spectrometry and immunoassay platforms, it aids in the detection and quantification of disease-related glycoforms. The compound's specificity for certain carbohydrate-binding proteins makes it a valuable tool for validating the diagnostic potential of glycan markers in biological samples. Through these diverse research applications, CYT-1010 continues to drive innovation in the fields of glycobiology, neuropharmacology, and molecular diagnostics, supporting the development of new scientific insights and experimental approaches.
3. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
4. The spatiotemporal control of signalling and trafficking of the GLP-1R
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