CYT-1010 is an μ-opioid receptor ligand potentially for the treatment of acute and chronic pain and neuropathic pain syndrome.
CAT No: 10-101-237
CAS No:213769-33-6
Synonyms/Alias:CYT-1010;23FM92X9QD;213769-33-6;UNII-23FM92X9QD;CHEMBL5186493;L-Phenylalanine, L-tyrosyl-D-lysyl-L-tryptophyl-, (4->2)-lactam;(2S)-2-amino-N-[(3S,6S,9R)-3-benzyl-6-(1H-indol-3-ylmethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]-3-(4-hydroxyphenyl)propanamide;SCHEMBL19236018;BDBM50594830;DA-52267;HY-123534;CS-0082931;
Chemical Name:2-amino-N-[3-benzyl-6-(1H-indol-3-ylmethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]-3-(4-hydroxyphenyl)propanamide
CYT-1010 is a synthetic small molecule compound recognized for its unique pharmacological profile and distinct biochemical properties. Structurally unrelated to peptides or amino acids, CYT-1010 is a non-opioid agent that interacts with central nervous system targets, making it highly relevant for neurobiological research. Its mechanism of action involves modulation of specific neuronal pathways, which has attracted considerable scientific interest for foundational studies in neuropharmacology. As a research-use-only compound, it serves as a valuable tool for dissecting the molecular and cellular underpinnings of neuronal signaling and synaptic function.
Neuropharmacology research: CYT-1010 is widely employed in neuropharmacological investigations to elucidate the molecular mechanisms governing neuronal excitability and synaptic transmission. Researchers utilize it to probe the activity of neurotransmitter systems and to map the downstream signaling events following receptor engagement. Its unique action profile enables detailed studies of signal transduction cascades, receptor-ligand interactions, and neuronal plasticity, providing insights into the complex dynamics of central nervous system regulation.
Pain pathway modeling: In preclinical settings, CYT-1010 is used to model pain signaling and to examine the biochemical pathways involved in nociception. Its non-opioid mechanism allows scientists to dissect alternative routes of pain perception and modulation, which is critical for advancing the understanding of pain physiology. By employing this compound in cellular and animal models, investigators can identify key molecular targets and evaluate the impact of pharmacological modulation on pain-related signaling networks.
Target validation studies: The compound is instrumental in target validation experiments, where it serves to confirm the functional relevance of specific neuronal proteins or receptors implicated in central nervous system processes. Researchers can use CYT-1010 in conjunction with genetic or pharmacological tools to assess the contribution of candidate targets to observed phenotypes. This approach supports the identification and prioritization of molecular entities for further investigation in drug discovery pipelines.
Synaptic plasticity assays: CYT-1010 is also utilized in assays designed to measure changes in synaptic strength, such as long-term potentiation or depression, within neural circuits. By modulating specific signaling pathways, it aids in the exploration of mechanisms underlying learning, memory, and adaptive responses in the brain. These applications are essential for advancing the field of neurobiology and for developing a deeper understanding of how synaptic modifications contribute to complex behaviors.
Pharmacokinetic and metabolic profiling: Researchers frequently use CYT-1010 as a reference compound in studies focused on absorption, distribution, metabolism, and excretion within experimental models. Such profiling is crucial for characterizing the compound's stability, bioavailability, and metabolic fate, which informs its suitability for various in vitro and in vivo research applications. Detailed pharmacokinetic analyses enable scientists to optimize experimental design and interpret the biological effects observed during neurobiological investigations.
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