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  5. (D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P

(D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P

(D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P is a modified substance P analog with D-arginine, D-phenylalanine, and D-tryptophan substitutions, which enhance receptor binding and stability. The peptide modulates neurogenic inflammation and pain transmission. Researchers use it to study the effects of substance P on pain pathways, neurogenic inflammation, and receptor dynamics across various tissues.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
(D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P(CAS 96736-12-8)

CAT No: G04014

CAS No:96736-12-8

Synonyms/Alias:96736-12-8;rPKPfQwFwLL-NH2;[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P;Antagonist D;MFCD00076802;CHEMBL501261;RPKPFQWFWLL;D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2;(D-Arg1,D-Phe5,D-Trp7.9,Leu11)-Substance P;[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P;L-Leucinamide,D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-;BDBM50260268;AKOS024456872;FA109992;HY-103544;CS-0028072;(D-Arg1,D-Phe5,D-Trp7?9,Leu11)-Substance P;[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P, >=95% (HPLC);D-Arg(1)-Pro(2)-Lys(3)-Pro(4)-D-Phe(5)-Gln(6)-D-Trp(7)-Phe(8)-D-Trp(9)-Leu(10)-Leu(11)-NH(2);H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; H-(dR)PKP(dF)Q(dW)F(dW)LL-NH2;

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C79H109N19O12
M.W/Mr.
1516.8
Sequence
One Letter Code:RPKPFQWFWLL
Three Letter Code:H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
InChI
InChI=1S/C79H109N19O12/c1-46(2)38-59(68(83)100)91-70(102)60(39-47(3)4)92-73(105)64(43-51-45-88-56-28-14-12-25-53(51)56)95-72(104)61(40-48-20-7-5-8-21-48)93-74(106)63(42-50-44-87-55-27-13-11-24-52(50)55)94-69(101)57(32-33-67(82)99)89-71(103)62(41-49-22-9-6-10-23-49)96-76(108)66-31-19-37-98(66)78(110)58(29-15-16-34-80)90-75(107)65-30-18-36-97(65)77(109)54(81)26-17-35-86-79(84)85/h5-14,20-25,27-28,44-47,54,57-66,87-88H,15-19,26,29-43,80-81H2,1-4H3,(H2,82,99)(H2,83,100)(H,89,103)(H,90,107)(H,91,102)(H,92,105)(H,93,106)(H,94,101)(H,95,104)(H,96,108)(H4,84,85,86)/t54-,57+,58+,59+,60+,61+,62-,63-,64-,65+,66+/m1/s1
InChI Key
XVOCEQLNJQGCQG-ACRSGXKRSA-N

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