Danegaptide Hydrochloride presents a designed peptide structure with charged and hydrophobic elements that govern folding and solubility. Researchers examine its conformational landscape and solvent responsiveness. The peptide aids studies of receptor interaction and motif mapping. Applications include structural biology, peptide engineering, and signaling analysis.
CAT No: R2688
CAS No:943133-81-1
Synonyms/Alias:943133-81-1;Danegaptide Hydrochloride;GAP-134 Hydrochloride;GAP-134 (Hydrochloride);ZP 1609 Hydrochloride;(2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid Hydrochloride;(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid;hydrochloride;GAP-134;AHXPMNACLWKFRQ-DHXVBOOMSA-N;CHEMBL453105;SCHEMBL2399462;DTXSID60659497;TMB13381;HY-10913A;AKOS027276401;CS-1101;DA-73655;MS-24899;F84886;Glycyl-(4R)-4-benzamido-L-proline--hydrogen chloride (1/1);
Danegaptide Hydrochloride is a synthetic dipeptide compound recognized for its ability to modulate gap junction communication in cellular systems. Structurally, it consists of two amino acid residues linked via a peptide bond, and its hydrochloride salt form enhances solubility and stability for laboratory use. As a gap junction modulator, Danegaptide Hydrochloride has garnered significant interest in biochemical and physiological research focused on intercellular signaling, cardiac electrophysiology, and tissue response to injury. Its unique mechanism of action, targeting connexin-mediated communication pathways, positions it as a valuable molecular tool for investigating cell-cell interactions and the regulation of electrical and metabolic coupling in various tissue types.
Gap Junction Modulation: One of the primary applications of Danegaptide Hydrochloride lies in the study of gap junction channels, particularly those formed by connexin proteins such as connexin43. By influencing the conductance and permeability of these channels, the compound enables researchers to dissect the molecular mechanisms underlying synchronized cellular activity. This is especially relevant in excitable tissues like cardiac muscle, where precise intercellular communication is essential for coordinated contraction. Utilizing Danegaptide Hydrochloride in in vitro and ex vivo models allows scientists to explore how modulation of gap junctions affects tissue function, arrhythmogenesis, and response to physiological stressors.
Electrophysiological Research: Danegaptide Hydrochloride serves as a valuable reagent in electrophysiological investigations, where it is used to assess the functional consequences of altered gap junction coupling. By applying the compound to cultured cells, tissue slices, or engineered cardiac constructs, researchers can quantify changes in action potential propagation, conduction velocity, and synchronization of electrical signals. This facilitates a deeper understanding of the role of intercellular connectivity in both normal and pathological states, supporting the development of new experimental models for arrhythmia and conduction disorders.
Ischemia and Reperfusion Studies: The compound is frequently employed in experimental protocols designed to mimic ischemic and reperfusion conditions in cardiac and other tissues. By modulating gap junctional communication during these events, Danegaptide Hydrochloride enables the study of cellular injury, survival pathways, and the influence of intercellular signaling on tissue recovery. Researchers leverage its properties to investigate the dynamics of metabolic and ionic exchange during periods of oxygen deprivation and subsequent reoxygenation, providing insights into the cellular mechanisms that govern tissue resilience and injury propagation.
Peptide Mechanism Exploration: As a synthetic dipeptide, Danegaptide Hydrochloride also serves as a model compound for elucidating structure-activity relationships in peptide-based modulators of cell signaling. Its defined sequence and functional activity make it a suitable candidate for comparative studies with other peptide analogs, supporting the rational design of new molecules targeting connexin channels or related signaling pathways. Researchers use it to probe the specific amino acid interactions and conformational features that underlie selective modulation of gap junctions, advancing the field of peptide therapeutics and research tools.
Cellular Communication Analysis: Beyond its applications in cardiac and excitable tissues, Danegaptide Hydrochloride is utilized in broader cellular communication studies involving diverse cell types and organ systems. Its ability to selectively influence gap junctional intercellular communication enables investigation into processes such as coordinated cellular responses, tissue patterning, and the regulation of multicellular networks. By incorporating the compound into experimental protocols, scientists can delineate the contribution of gap junctions to developmental biology, tissue engineering, and the maintenance of homeostatic signaling across cell populations.
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