Danegaptide Hydrochloride presents a designed peptide structure with charged and hydrophobic elements that govern folding and solubility. Researchers examine its conformational landscape and solvent responsiveness. The peptide aids studies of receptor interaction and motif mapping. Applications include structural biology, peptide engineering, and signaling analysis.
CAT No: R2688
CAS No:943133-81-1
Synonyms/Alias:943133-81-1;Danegaptide Hydrochloride;GAP-134 Hydrochloride;GAP-134 (Hydrochloride);ZP 1609 Hydrochloride;(2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid Hydrochloride;(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid;hydrochloride;GAP-134;AHXPMNACLWKFRQ-DHXVBOOMSA-N;CHEMBL453105;SCHEMBL2399462;DTXSID60659497;TMB13381;HY-10913A;AKOS027276401;CS-1101;DA-73655;MS-24899;F84886;Glycyl-(4R)-4-benzamido-L-proline--hydrogen chloride (1/1);
Danegaptide Hydrochloride is a synthetic dipeptide compound recognized for its unique ability to modulate intercellular communication through gap junctions. As a water-soluble peptide derivative, it is widely utilized in various research settings due to its stability, ease of handling, and high specificity for connexin-mediated signaling pathways. The compound's structure allows it to interact with connexin proteins, influencing the permeability and functional state of gap junction channels. This capacity has established Danegaptide Hydrochloride as a valuable tool in elucidating the physiological and pathological roles of gap junctions in diverse cell types and tissues. Researchers benefit from its targeted action, which enables precise modulation of cellular communication without broadly affecting unrelated cellular processes.
Cardiac Electrophysiology Research: In the field of cardiac electrophysiology, Danegaptide Hydrochloride is frequently employed to study the mechanisms underlying arrhythmias and impaired conduction. By enhancing gap junctional conductance, it helps maintain synchronized electrical signaling between cardiomyocytes, providing insights into the prevention of conduction block and arrhythmic events. Investigators use it to model conditions of ischemic stress or to test novel therapeutic strategies aimed at preserving cardiac function during adverse events. Its application enables the dissection of connexin43-dependent pathways, facilitating a deeper understanding of heart rhythm regulation and intercellular electrical coupling.
Neuroprotection and Brain Injury Models: Another prominent application for Danegaptide Hydrochloride is in neurobiology, particularly in studies focused on neuroprotection and brain injury. The compound's ability to modulate gap junction communication in neural tissues has made it instrumental in exploring the propagation of injury signals, such as during ischemia or traumatic brain injury. Researchers utilize it to investigate the mechanisms by which intercellular signaling contributes to secondary neuronal damage, with the goal of identifying interventions that may limit the spread of injury. Its selective targeting of connexin channels allows for precise manipulation of neural network responses, advancing our understanding of brain resilience and recovery.
Renal Physiology and Pathophysiology: In renal research, Danegaptide Hydrochloride is leveraged to explore gap junction-dependent processes within the kidney. Its modulatory effects on connexin-mediated communication have proven valuable in dissecting the roles of intercellular signaling in glomerular and tubular function. Scientists employ the compound to study how alterations in gap junction dynamics impact renal hemodynamics, filtration, and cellular responses to injury or stress. Through these investigations, new insights have emerged regarding the maintenance of kidney homeostasis and the potential for targeting gap junctions in the context of renal disorders.
Vascular Biology and Endothelial Function: The compound finds further application in vascular biology, where it serves as a key tool for examining the regulation of endothelial cell communication and vascular tone. Danegaptide Hydrochloride's influence on gap junctions enables researchers to probe the mechanisms underlying coordinated responses among vascular cells, including the propagation of vasodilatory or vasoconstrictive signals. By modulating connexin activity, it aids in characterizing the contribution of intercellular communication to vascular integrity, permeability, and adaptation to physiological or pathological stimuli.
Pharmacological Screening and Connexin Modulator Development: In the context of drug discovery, Danegaptide Hydrochloride is utilized as a reference compound or positive control in pharmacological screening assays aimed at identifying novel modulators of gap junctions. Its well-characterized mode of action provides a benchmark for evaluating the efficacy and specificity of new chemical entities targeting connexin proteins. Researchers incorporate the compound into high-throughput screening platforms to validate assay sensitivity, optimize experimental conditions, and compare the potency of candidate molecules. This application accelerates the development of next-generation gap junction modulators for basic and translational research, supporting the ongoing exploration of intercellular communication pathways in health and disease.
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