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  5. delta PKC (8-17); PKC d Inhibitor

delta PKC (8-17); PKC d Inhibitor

This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: X21142

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.W/Mr.
1116.2
Sequence
One Letter Code: SFNSYELGSL
Three Letter Code: H-Ser-Phe-Asn-Ser-Tyr-Glu-Leu-Gly-Ser-Leu-OH
References
1. Bright, R. et al. J Neurosci 24, 6880 (2004).
2. Tanaka, M. et al. Circulation 110, 194 (2004).
3. Braun, M and D. Mochly-Rosen. J Mol Cell Cardiol 35 895 (2003).
4. Chen, L. et al. Proc Natl Acad Sci USA 98, 11114 (2001).

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