DEPBT contains a protected amino acid framework in which the amino and carboxyl functionalities are masked by protecting groups, enabling chemoselective handling during stepwise peptide-related synthesis. The molecule bears a side-chain substituent characteristic of its amino acid class and retains the stereochemical information only to the extent specified by its structure, while the protected termini prevent undesired amide formation or decarboxylation under coupling conditions. DEPBT is used as a protected amino acid building block or intermediate for assembling peptides and peptide analogues, including applications in solid-phase or solution-phase synthetic routes where controlled reactivity of the protected functional groups supports sequential elongation and side-chain functionalization.
CAT No: CP26465
CAS No:165534-43-0
Synonyms/Alias:3-(Diethoxy-phosphoryloxy)-1,2,3-benzo[d]triazin-4(3H)-one;165534-43-0;DEPBT;3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one;3-(Diethoxyphosphoryloxy)-1,2,3-benzotrizin-4(3H)-one;Diethyl(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)phosphate;MFCD01236967;SBB059481;3-(diethoxyphosphoryloxy)-3h-benzo[d][1,2,3]triazin-4-one;diethyl(4-oxo-1,2,3-benzotriazin-3-yl)phosphate;3-diethoxyphosphoryloxy-1,2,3-benzotriazin-4(3h)-one;3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4-(3h)-one;diethyl4-oxobenzo[d][1,2,3]triazin-3(4h)-ylphosphate;3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3h)-one;diethyl4-oxobenzo[d]1,2,3-triazin-3-ylphosphate;495964_ALDRICH;PubChem12710;ACMC-209dsm;AC1N8E2T;SCHEMBL76069;KSC490C6T;C11H14N3O5P;CTK3J0169;AJDPNPAGZMZOMN-UHFFFAOYSA-N;MolPort-000-165-528;ZINC2573666
DEPBT is a specialized amino acid derivative used as a reactive building block in peptide and chemical synthesis workflows. Its designation reflects a functionalized, protected amino acid-type reagent format designed to participate in downstream coupling or derivatization steps rather than serving as a free amino acid for biological assays. In research and development settings, DEPBT is typically selected when a specific side-chain functionality and controlled reactivity are required to assemble defined intermediates or incorporate a targeted residue-like motif into larger molecular constructs.
1. Pharmaceutical Intermediate Synthesis
DEPBT is used by medicinal chemistry and process development groups to access defined amino-acid-derived intermediates for subsequent coupling steps toward peptidomimetics and structure-defined small molecules. Teams developing route-planned synthesis often choose this reagent form because it provides controlled functional-group behavior during intermediate assembly, enabling predictable downstream transformations and streamlined purification strategies when compared with less functionalized starting materials. In custom synthesis and catalog intermediate workflows, DEPBT supports the preparation of well-characterized building blocks used in iterative medicinal chemistry campaigns.
2. Peptide Building Block Coupling
DEPBT is commonly employed in peptide synthesis workflows where a functionalized amino acid derivative is required to introduce a residue-like unit with defined reactivity. Peptide chemistry groups use this type of reagent to prepare segments or modified peptide intermediates that can be carried forward into solid-phase or solution-phase assembly, depending on the coupling strategy used in the lab. The value of DEPBT in these workflows lies in its ability to deliver a controlled coupling handle and side-chain presentation, helping researchers generate peptides with specific structural features for sequence optimization, SAR studies, or mechanistic peptide variants.
3. Chemical Biology Probe Intermediates
DEPBT is also used to prepare amino-acid-derived intermediates for chemical biology research, particularly when a defined functional motif is needed as part of a probe scaffold or labeling reagent precursor. Chemical biology teams often rely on these intermediates to build larger constructs that later undergo conjugation, attachment to biomolecular targets, or incorporation into assay-ready materials. Because DEPBT is supplied as a reactive, synthesis-oriented derivative rather than a free amino acid, it fits naturally into workflows focused on construct assembly, where controlled reactivity and compatibility with downstream derivatization steps are key selection criteria.
4. Custom Peptide and Derivative Manufacturing
DEPBT is frequently selected by custom peptide manufacturing and specialty chemical synthesis providers that require reliable access to specialized amino-acid-derived building blocks for client-specific targets. In these settings, DEPBT supports the production of modified peptide intermediates and derivative series where consistent reagent performance and defined functional-group positioning are important for reproducibility across batches. Project teams use DEPBT to reduce development iteration time when a particular functionalized amino acid motif must be introduced into a larger synthetic sequence with clear structure control.
1. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
2. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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