Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.
CAT No: R1340
CAS No:2990-43-4
Synonyms/Alias:2990-43-4;Lpiglm;Lysyl-phenylalanyl-isoleucyl-glycyl-leucyl-methioninamide;Lys-phe-ile-gly-leu-met-amide;DTXSID60184017;L-Methioninamide, L-lysyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-;(2S)-2,6-diamino-N-[(2S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]hexanamide;Eledoisin RP;Eledoisin-Related Peptide TFA;DTXCID70106508;HY-P1186;AKOS024456857;DA-52853;CS-0028920;G12222;(2S)-2,6-diamino-N-[(1S)-1-{[(1S,2S)-1-[({[(1S)-1-{[(1S)-1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl]carbamoyl}methyl)carbamoyl]-2-methylbutyl]carbamoyl}-2-phenylethyl]hexanamide;(S)-2,6-diamino-N-((5S,8S,14S,17S)-14-sec-butyl-5-carbamoyl-8-isobutyl-7,10,13,16-tetraoxo-18-phenyl-2-thia-6,9,12,15-tetraazaoctadecan-17-yl)hexanamide;
Eledoisin Related Peptide is a synthetic peptide compound structurally analogous to eledoisin, a naturally occurring tachykinin neuropeptide originally isolated from octopus salivary glands. As a member of the tachykinin peptide family, it is characterized by its distinctive amino acid sequence and its ability to interact with neurokinin receptors, making it a valuable tool in neuropharmacological and receptor biology research. Its unique bioactivity profile and structural features provide researchers with a versatile platform for probing peptide-receptor interactions, dissecting signaling pathways, and developing novel experimental models in neurobiology and peptide science.
Receptor Pharmacology: In experimental pharmacology, eledoisin-related analogs are widely used to investigate the activation and selectivity of tachykinin receptors, particularly neurokinin-1 (NK1), neurokinin-2 (NK2), and neurokinin-3 (NK3) subtypes. By serving as reference agonists or comparative ligands in binding and functional assays, these peptides help elucidate receptor affinity, specificity, and downstream signaling mechanisms. Such studies are crucial for mapping receptor distribution, understanding ligand-receptor dynamics, and supporting the design of new receptor modulators.
Signal Transduction Studies: The peptide's ability to trigger G protein-coupled receptor (GPCR) signaling cascades makes it an essential probe for dissecting intracellular pathways activated by tachykinins. Researchers utilize it to monitor calcium mobilization, second messenger production, and kinase activation in cell-based assays. These applications enable detailed characterization of cellular responses to peptide stimulation, facilitating insight into the molecular mechanisms underlying neurotransmission, smooth muscle contraction, and inflammatory responses.
Peptide Structure-Activity Relationship (SAR) Analysis: Eledoisin-related peptides are instrumental in SAR studies aimed at identifying the structural determinants of biological activity within the tachykinin family. By introducing specific amino acid substitutions or modifications, scientists can assess the impact on receptor binding, potency, and selectivity. Such research advances the rational design of more potent or selective peptide ligands, supporting both basic research and the development of peptide-based tools for neurobiological investigations.
Neurobiology and Sensory Research: The compound is frequently employed in studies exploring the physiological roles of tachykinins in neuronal communication and sensory processing. Its application in ex vivo tissue preparations or neuronal cell cultures allows for the assessment of neurotransmitter release, neuronal excitability, and synaptic plasticity. These investigations contribute to a deeper understanding of the modulation of pain pathways, autonomic control, and neuroimmune interactions mediated by tachykinin peptides.
Peptide Synthesis and Analytical Method Development: As a structurally defined peptide, eledoisin-related analogs are also utilized as standards and reference materials in peptide synthesis optimization and analytical method validation. Their well-characterized sequence and physicochemical properties make them suitable for calibrating chromatographic techniques, mass spectrometry, and peptide quantification protocols. This supports quality control and assay development in both research and peptide manufacturing environments, ensuring reproducibility and accuracy in experimental workflows.
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