Synthetic, dendrimeric peptide, Epobis is derived from the sequence of human EPO. This peptide binds the EPO receptor and promotes neuritogenesis and neuronal cell survival.
CAT No: R1828
Epobis is a synthetic peptide compound designed to mimic specific functional motifs of erythropoietin (EPO), a key hematopoietic growth factor. As a peptide-based research tool, Epobis is structurally engineered to engage cellular signaling pathways associated with EPO but is distinct from the full-length glycoprotein in both size and receptor interaction profile. Its unique sequence and conformational properties enable targeted modulation of EPO-associated biological processes, making it a valuable asset for dissecting peptide-receptor interactions, exploring neuroprotective mechanisms, and advancing peptide therapeutic research. The compound's biochemical relevance is underscored by its capacity to facilitate mechanistic studies in cell signaling, tissue protection, and peptide-based drug discovery.
Peptide-receptor interaction studies: Epobis is utilized extensively in research focused on the characterization of peptide-receptor binding events, particularly those involving the erythropoietin receptor (EPOR) and related signaling complexes. By providing a defined and reproducible peptide sequence, it allows investigators to delineate the minimal structural requirements for receptor activation or antagonism, facilitating the mapping of ligand-receptor interfaces. Such studies are instrumental in understanding the molecular determinants of specificity and affinity within the EPO signaling axis, supporting the rational design of novel peptide ligands and receptor modulators.
Cell signaling pathway elucidation: Researchers employ Epobis to probe downstream signaling cascades triggered by EPO-mimetic peptides, including the activation of JAK2/STAT5, PI3K/AKT, and MAPK pathways. Through controlled application in cellular models, the peptide enables precise dissection of pathway activation kinetics, cross-talk with other growth factor signals, and the identification of key regulatory nodes. These investigations contribute to a deeper understanding of how EPO-derived peptides influence cell survival, proliferation, and differentiation, informing broader studies in hematopoiesis and tissue homeostasis.
Neuroprotection mechanism research: The neuroprotective properties attributed to EPO and its analogs have spurred interest in Epobis as a tool for studying peptide-mediated protection in neural cell models. Researchers utilize the compound to investigate its effects on neuronal viability, oxidative stress responses, and apoptosis under experimental conditions that simulate neurodegenerative stressors. Such studies help clarify the molecular underpinnings of peptide-induced neuroprotection, offering insights into the potential of EPO-mimetic peptides for supporting neuronal resilience in vitro.
Peptide drug discovery and lead optimization: In the context of peptide-based drug discovery, Epobis serves as a reference compound for evaluating structure-activity relationships and optimizing lead candidates. Its well-characterized sequence and biological activity profile enable medicinal chemists to benchmark new analogs, assess modifications for enhanced stability or selectivity, and streamline the development of next-generation peptide therapeutics. The compound's utility in early-stage screening assays accelerates the identification of promising candidates for further preclinical investigation.
Analytical method development: Analytical laboratories leverage Epobis as a standard or control peptide in the development and validation of peptide quantification and detection methodologies. Its defined composition makes it suitable for calibrating mass spectrometry, HPLC, and immunoassay platforms, supporting rigorous quality control and reproducibility in peptide analytics. By providing a reliable benchmark, it aids in ensuring the accuracy and sensitivity of analytical workflows essential for peptide research and bioprocess monitoring.
2. Emu oil in combination with other active ingredients for treating skin imperfections
4. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More