An impurity of Felypressin. Felypressin is a Vasopressin 1 agonist, and will thus have effects at all Arginine vasopressin receptor 1As. It physiologically effects on vascular SMC's due to the form in which it is administered. Its receptors are found in various sites around the body. The major points include the CNS, Liver, Anterior Pituitary, Muscle (both vascular and non-vascular smooth muscle), and Platelets (CLAMP).
CAT No: 10-101-193
Synonyms/Alias:[4-glutamic acid]felypressin;3-((4R,7S,10S,13S,16S,19R)-19-amino-4-((S)-2-(((S)-6-amino-1-((2-amino-2-oxoethyl)amino)-1-oxohexan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-7-(2-amino-2-oxoethyl)-13,16-dibenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-10-yl)propanoic acid
Felypressin Impurity F is a peptide compound that serves as a structurally related analogue and process-related impurity of felypressin, a synthetic vasopressin analog. As a peptide impurity, it holds significant importance in the context of peptide synthesis, analytical method development, and quality control for research and industrial peptide production. Its biochemical relevance derives from its close relationship to the parent peptide, making it a valuable reference standard for impurity profiling, stability testing, and the optimization of peptide manufacturing processes. Felypressin Impurity F is widely utilized in laboratories focused on peptide chemistry, pharmaceutical research, and analytical science, where precise characterization of peptide-related impurities is essential for ensuring product integrity and regulatory compliance in research settings.
Analytical method validation: Felypressin Impurity F is frequently used as a reference standard in the validation of analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). By incorporating this impurity into method development protocols, researchers can assess the specificity, sensitivity, and accuracy of their analytical procedures for detecting and quantifying trace-level impurities in peptide preparations. The presence of well-characterized impurities enables laboratories to establish robust quality control measures, ensuring that analytical methods can reliably distinguish between the main peptide and structurally similar byproducts.
Peptide synthesis optimization: In the context of synthetic peptide production, Felypressin Impurity F provides critical insight into potential side reactions and degradation pathways that may occur during solid-phase peptide synthesis or solution-phase assembly. Monitoring the formation and levels of this impurity allows chemists to refine synthetic protocols, adjust reaction conditions, and select appropriate purification strategies to minimize impurity content. Such optimization is essential for improving yield, purity, and reproducibility in research-scale and industrial peptide synthesis workflows.
Impurity profiling and characterization: The availability of Felypressin Impurity F supports comprehensive impurity profiling studies, which are necessary for understanding the full impurity landscape associated with felypressin and its analogues. Detailed characterization of this impurity, including its retention time, mass spectral properties, and chromatographic behavior, aids in the identification and quantification of related species during batch release testing and stability studies. This information is crucial for establishing impurity limits and ensuring the consistency of peptide-based research products.
Stability studies: Incorporating Felypressin Impurity F into forced degradation and stability studies enables researchers to monitor the formation and evolution of process-related impurities under various stress conditions, such as exposure to heat, light, moisture, or oxidative environments. By tracking the generation of this impurity over time, scientists can better understand the degradation mechanisms of felypressin formulations and develop strategies to enhance the stability and shelf life of research-grade peptide products.
Process control in manufacturing: In industrial and research peptide manufacturing settings, the use of Felypressin Impurity F as a process marker allows for the ongoing assessment of process consistency and impurity clearance during scale-up and batch production. Quantitative monitoring of this impurity informs process adjustments and purification decisions, supporting continuous improvement initiatives and ensuring that research-use peptide products meet stringent quality expectations. The integration of impurity standards like this one is a key component of robust process analytical technology (PAT) frameworks in modern peptide manufacture.
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