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This peptide is a fusion of A208, derived from murine laminin a1, and the active site of fibronectin (GRGDS), with a glycine spacer. This peptide forms amyloid-like fibrils and promotes formation of actin stress fibers that mediate fibroblast cell attachment, offering it potential as a bioadhesive for tissue regeneration and engineering. FN-A208 interacts with IKVAV receptors and integrins. Its activity is disrupted by the presence of EDTA.
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M.W/Mr. | 1717 |
Sequence | One Letter Code: GRGDSGAASIKVAVSADR Three Letter Code: H-Gly-Arg-Gly-Asp-Ser-Gly-Ala-Ala-Ser-Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg-OH |
References | 1. Ohga, Y. et al. Biomater. 30, 6731 (2009). 2. Kasai, S. et al. Biopolymers Pept. Sci. 76, 27 (2004). |
1. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
4. Myotropic activity of allatostatins in tenebrionid beetles
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