Fostamatinib works by inhibiting spleen tyrosine kinase (SYK), which plays a role in the immune response. By blocking this enzyme, fostamatinib helps to reduce the destruction of platelets by the immune system, thereby increasing platelet counts in patients with ITP.
CAT No: R2245
CAS No: 901119-35-5
Chemical Name: [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate
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M.F/Formula | C23H26FN6O9P |
M.W/Mr. | 580.46 |
Appearance | White to off-white Solid |
Target | Syk, FLT3 |
InChI | InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29) |
InChI Key | GKDRMWXFWHEQQT-UHFFFAOYSA-N |
Canonical SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C |
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