FX-06, a peptide-based pharmaceutical, exhibits remarkable efficacy in the research for mitigating inflammation and averting tissue deterioration. The mechanism of action revolves around bolstering endothelial barrier integrity, curtailing vascular permeability, as well as hampering neutrophil activation and migration. The progressive nature of this groundbreaking innovation instills considerable optimism concerning enhanced patient prognoses and the resolution of unaddressed medical exigencies.
CAT No: R1975
CAS No:88650-17-3
Chemical Name:(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-carboxybutanoyl]amino]-5-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[(2S)-2-[[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[[(2S,3S)-1-[[(2S)-1-[[2-[[2-[[2-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
FX-06 is a synthetic peptide derived from the N-terminus of the human fibrin β-chain, belonging to the class of fibrin-derived peptides. As a bioactive oligopeptide, it has garnered significant research interest due to its involvement in modulating vascular permeability and its interaction with cellular and extracellular matrix components. Its unique sequence and biochemical properties make it a valuable tool for probing mechanisms of vascular biology, inflammation, and peptide-receptor interactions. Researchers utilize FX-06 to study the dynamic interplay between fibrin fragments and cellular processes, as well as to develop new insights into the molecular underpinnings of tissue injury and repair.
Vascular biology research: FX-06 serves as a critical reagent in the study of endothelial barrier function and vascular permeability. In vitro and in vivo models leverage its ability to interact with cellular adhesion molecules, allowing researchers to dissect the molecular mechanisms that regulate endothelial integrity. By modulating the activity of specific signaling pathways, the peptide enables detailed investigations into the factors that contribute to capillary leakage and the maintenance of vascular homeostasis, providing a foundation for understanding pathophysiological changes during inflammation or tissue injury.
Peptide-receptor interaction studies: The sequence of FX-06 is recognized for its affinity to certain integrins and cellular receptors, making it a powerful probe for characterizing peptide-receptor interactions. Researchers employ it to map binding sites, quantify affinity constants, and elucidate downstream signaling events triggered by fibrin-derived peptides. These studies are essential for advancing knowledge of how extracellular matrix fragments influence cellular behavior, migration, and communication within the vascular microenvironment.
Inflammation modeling: Due to its origin from fibrin and its modulatory effects on cellular responses, FX-06 is utilized in experimental systems designed to mimic inflammatory conditions. Scientists apply the peptide in models of acute and chronic inflammation to investigate how fibrin fragments contribute to leukocyte recruitment, cytokine release, and tissue remodeling. Such applications support the identification of novel molecular targets involved in the inflammatory cascade and facilitate the study of the interface between coagulation and immune responses.
Peptide structure-activity relationship (SAR) analysis: The defined sequence and functional motifs within FX-06 make it an excellent candidate for SAR studies. By synthesizing analogs or introducing targeted modifications, researchers can systematically evaluate how structural changes impact biological activity and receptor binding. These experiments provide valuable insights into the critical determinants of peptide function and inform the rational design of next-generation bioactive peptides for basic research or biotechnological applications.
Analytical method development: FX-06 is also employed as a reference or model peptide in the optimization of analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and capillary electrophoresis. Its physicochemical properties and defined sequence make it suitable for calibrating instruments, validating peptide quantitation protocols, and assessing method sensitivity. These analytical applications are essential for ensuring reproducibility and accuracy in peptide research and quality control processes.
1. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
2. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review
3. Implications of ligand-receptor binding kinetics on GLP-1R signalling
4. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More