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GPS1573 Peptide

GPS1573 is a newly described potent and dose-dependent peptide antagonist of ACTH-stimulated melanocortin type 2 receptor (MC2R) activity in vitro (IC50 = 66 nM). GPS1573 antagonizes MC4R with IC50 of 950 nM, therefore showing selectivity for MC2R. The binding of ACTH to MC2R regulates steroidogenesis leading to metabolic diseases such as Cushing's disease in patients with pituitary dysfunctions.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: A03042

Synonyms/Alias:GPS1573; MC2R antagonist; Adrenocorticotropic hormone receptor antagonist

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cGMP Peptide
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M.F/Formula
C86H139N27O16
M.W/Mr.
1807
Sequence
Three-Letter Code: H-Nle-Pro-(D-Phe)-Arg-(D-Trp)-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-NH2
One-Letter Code: H-Nle-PfRwFKAVGKKRR-NH2
Purity
Purity > 95% by HPLC
Length
7

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