Historphin offers a peptide motif with diverse functional groups that influence folding, solubility, and molecular recognition. Researchers investigate its conformational transitions and hydrogen-bond networks. Its amphipathic character aids binding-site modeling. Applications span structural biology, peptide engineering, and sequence-activity studies.
CAT No: R2342
CAS No:105250-85-9
Synonyms/Alias:105250-85-9;Historphin;Osteogenic Growth Peptide (10-14);Tyrosyl-glycyl-phenylalanyl-glycyl-glycine;Tyr-gly-phe-gly-gly;H-Tyr-Gly-Phe-Gly-Gly-OH;ogp(10-14);2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]acetic acid;Osteogenic Growth Peptide (10-14) trifluoroacetate salt;Glycine, N-(N-(N-(N-L-tyrosylglycyl)-L-phenylalanyl)glycyl)-;CHEMBL43978;DTXSID10909398;Osteogenic growth peptide(10-14);AKOS040755928;DA-76478;FO109638;MS-29276;H-Tyr-Gly-Phe-Gly-Gly-OH; H-YGFGG-OH;HY-107024;CS-0027162;G13481;N-[2-({2-[(2-{[2-Amino-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxy-3-phenylpropylidene}amino)-1-hydroxyethylidene]glycine;
Historphin is a synthetic peptide compound that belongs to the class of opioid peptides, recognized for its structural relation to enkephalins and its potential interaction with opioid receptors. As a research-grade peptide, it serves as a valuable molecular tool for probing the physiological and biochemical pathways associated with endogenous opioid systems. Its unique sequence and receptor affinity profile make it relevant for studies aiming to unravel the nuances of neuropeptide signaling, receptor selectivity, and the broader landscape of peptide-mediated modulation within the central nervous system and peripheral tissues.
Receptor binding studies: Historphin is widely utilized in receptor binding assays to investigate the specificity and affinity of endogenous and exogenous ligands for opioid receptor subtypes. Through radioligand displacement or fluorescence-based techniques, researchers employ this peptide to characterize the pharmacological properties of mu, delta, and kappa opioid receptors. Such studies facilitate a deeper understanding of ligand-receptor interactions, aiding in the mapping of receptor distribution and the elucidation of structure-activity relationships critical for neuropharmacological research.
Peptide signaling pathway analysis: The compound is instrumental in dissecting the intracellular signaling cascades initiated by peptide-receptor engagement. By serving as a selective agonist or antagonist in cellular models, it enables the assessment of downstream effects such as G-protein activation, second messenger modulation, and gene expression changes. This application is particularly valuable for delineating the molecular mechanisms underlying opioid peptide function and for identifying potential cross-talk with other neurotransmitter systems.
Neurochemical research: Historphin is frequently applied in neurochemical investigations to explore the modulation of neurotransmitter release and synaptic plasticity. Its use in in vitro and ex vivo systems allows researchers to quantify changes in neurotransmitter dynamics in response to peptide exposure, offering insights into the regulatory roles of opioid peptides in neural circuits. These studies are essential for advancing the understanding of neuropeptide influence on behavior, pain processing, and homeostatic regulation.
Peptide structure-activity relationship studies: The defined sequence and receptor interaction profile of Historphin make it a model substrate for structure-activity relationship (SAR) analyses. By systematically modifying specific amino acid residues or peptide termini, researchers can assess the impact of structural alterations on receptor binding and functional activity. Such investigations support the rational design of novel peptide analogs with tailored pharmacological properties and contribute to the development of new probes for opioid research.
Analytical method development: The compound also serves as a reference standard or calibration material in the development and validation of analytical techniques for peptide quantification and characterization. Its well-defined physicochemical properties make it suitable for optimizing chromatographic separation, mass spectrometry detection, and peptide mapping protocols. Employing Historphin in these contexts enhances the reliability and reproducibility of analytical workflows in peptide research laboratories.
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