ICI 174,864

A highly selective, potent antagonist for the opioid δ-receptor. It exhibits partial agonist in vitro activity at δ receptors at high concentrations.

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CAT No: R1076

CAS No: 89352-67-0

Synonyms/Alias: ICI 174,864;92535-15-4;N,N-diallyl-Tyr-Aib-Aib-Phe-Leu;89352-67-0;Ici 174865;Ici 174,865;N,N-Diallyl-tyr-aib-aib-phe-leu-OH;ICI-174865;ICI-174,865;CHEMBL47545;N,N-Diallyl-tyrosyl-aminoisobutyryl-aminoisobutyryl-phenylalanyl-leucine;L-Leucine, N-(N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-2-methylalanyl)-L-phenylalanyl)-;N-(N-(N-(N-(N,N-di-2-Propenyl-L-tyrosyl)-2-methylalanyl)-2-methylalanyl)-L-phenylalanyl)-L-leucine;(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[bis(prop-2-enyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-2-methylpropanoyl]amino]-2-methylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid;(2S,5S,14S)-15-allyl-5-benzyl-14-(4-hydroxybenzyl)-2-isobutyl-8,8,11,11-tetramethyl-4,7,10,13-tetraoxo-3,6,9,12,15-pentaazaoctadec-17-en-1-oic acid;NIH10893;DTXSID10919119;BDBM50006946;AKOS024458657;DA-54236;PD071343;CS-0134163;L-Leucine,N,N-di-2-propen-1-yl-L-tyrosyl-2-methylalanyl-L-phenylalanyl-;L-Leucine, N,N-di-2-propen-1-yl-L-tyrosyl-2-methylalanyl-2-methylalanyl-L-phenylalanyl-;2-[2-(2-{2-[2-Diallylamino-3-(4-hydroxy-phenyl)-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid;N-{2-Benzyl-1,4,7,10-tetrahydroxy-11-[(4-hydroxyphenyl)methyl]-5,5,8,8-tetramethyl-12-(prop-2-en-1-yl)-3,6,9,12-tetraazapentadeca-3,6,9,14-tetraen-1-ylidene}leucine;

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC38H53N5O7
M.W/Mr.691.9
SequenceOne Letter Code:YXXFL
Three Letter Code:N(allyl2)Tyr-Aib-Aib-Phe-Leu-OH
Labeling TargetOpioid Receptor
AppearanceWhite lyophilised solid
Purity>98%
ActivityAntagonist
Long-term Storage ConditionsSoluble in DMSO
InChIInChI=1S/C38H53N5O7/c1-9-20-43(21-10-2)31(24-27-16-18-28(44)19-17-27)33(46)41-38(7,8)36(50)42-37(5,6)35(49)40-29(23-26-14-12-11-13-15-26)32(45)39-30(34(47)48)22-25(3)4/h9-19,25,29-31,44H,1-2,20-24H2,3-8H3,(H,39,45)(H,40,49)(H,41,46)(H,42,50)(H,47,48)/t29-,30-,31-/m0/s1
InChI KeyXUWLAGNFLUARAN-CHQNGUEUSA-N
BoilingPoint892.7ºC at 760 mmHg
Melting PointN/A

1. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment

2. The spatiotemporal control of signalling and trafficking of the GLP-1R

3. C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients

4. High fat diet and GLP-1 drugs induce pancreatic injury in mice

5. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die

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