iRGD peptide
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
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| CAT# | R1458 |
| CAS | 1392278-76-0 |
| Synonyms/Alias | c(CRGDKGPDC) |
| M.F/Formula | C35H57N13O14S2 |
| M.W/Mr. | 948.04 |
| Sequence | One Letter Code: CRGDKGPDC)
Three Letter Code: Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys |
| Application | iRGD peptides have been shown to increase the accumulation and penetration of anticancer drugs in tumors, but not into normal tissues-regardless of whether the drug is coupled to or administered with the peptide. |
| Purity | 98% |
| Storage |
Protect from light
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month |
Solubility | H2O : ≥ 50 mg/mL (52.74 mM) |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
Canonical SMILES | O=C1[C@@]2([H])N(C(CNC([C@@H](NC([C@](NC(CNC([C@@](CCCNC(N)=N)([H])NC([C@@H](N)CSSC[C@@H](C(O)=O)NC([C@H](CC(O)=O)N1)=O)=O)= O)=O)([H])CC(O)=O)=O)CCCCN)=O)=O)CCC2 |
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