iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
CAT No: R1458
CAS No:1392278-76-0
Synonyms/Alias:iRGD peptide;c(CRGDKGPDC);1392278-76-0;UNII-Z8MXU5GH4Q;iRGD;(6S,9S,15S,18R,23R,26S,29S)-18-amino-6-(4-aminobutyl)-9,26-bis(carboxymethyl)-15-[3-(diaminomethylideneamino)propyl]-2,5,8,11,14,17,25,28-octaoxo-20,21-dithia-1,4,7,10,13,16,24,27-octazabicyclo[27.3.0]dotriacontane-23-carboxylic acid;CEND-1;iRGD-peptide;2,2'-((3S,6R,11R,14S,20S,23S,31aS)-11-amino-23-(4-aminobutyl)-6-carboxy-14-(3-guanidinopropyl)-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2]dithia[5,8,11,14,17,20,23,26]octaazacyclononacosine-3,20-diyl)diacetic acid;Z8MXU5GH4Q;NSC838763;NSC-838763;DA-64499;G16330;Internalized-arginylglycylaspartic acid cyclic peptide;Q48988348;(3S,6R,11R,14S,20S,23S,31aS)-11-amino-23-(4-aminobutyl)-14-(3-carbamimidamidopropyl)-3,20-bis(carboxymethyl)-1,4,12,15,18,21,24,27-octaoxo-icosahydro-2H-pyrrolo[2,1-j]1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-6-carboxylic acid;L-Cysteine, L-cysteinyl-L-arginylglycyl-L-alpha-aspartyl-L-lysylglycyl-L-prolyl-L-alpha-aspartyl-, cyclic (1->9)-disulfide;
3. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
4. Implications of ligand-receptor binding kinetics on GLP-1R signalling
5. Cationic cell-penetrating peptides are potent furin inhibitors
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