Irofulven

Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven is more active in vitro against tumor cells of epithelial origin and is more resistant to deactivation by p53 loss and MDR1 than other alkylating agents.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

Irofulven(CAS 158440-71-2)

CAT No: MFP-048

CAS No:158440-71-2

Synonyms/Alias:MGI 114; HMAF; 6-Hydroxymethylacylfulvene

Chemical Name:(5'R)-5'-hydroxy-1'-(hydroxymethyl)-2',5',7'-trimethylspiro[cyclopropane-1,6'-indene]-4'-one

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Drug master files (DMF) filing

M.F/Formula

C15H18O3

M.W/Mr.

246.3

InChI

InChI=1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1

InChI Key

NICJCIQSJJKZAH-AWEZNQCLSA-N

Canonical SMILES

CC1=C(C2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C)CO

Isomeric SMILES

CC1=C(C2=C(C3(CC3)[C@@](C(=O)C2=C1)(C)O)C)CO

1. Immune responses to peptides containing homocitrulline or citrulline in the DR4-transgenic mouse model of rheumatoid arthritis

2. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review

3. Effect of Short-Term Desiccation, Recovery Time, and CAPA-PVK Neuropeptide on the Immune System of the Burying Beetle Nicrophorus vespilloides

4. TMEM16F and dynamins control expansive plasma membrane reservoirs

5. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy

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