Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven is more active in vitro against tumor cells of epithelial origin and is more resistant to deactivation by p53 loss and MDR1 than other alkylating agents.
CAT No: MFP-048
CAS No: 158440-71-2
Synonyms/Alias: MGI 114; HMAF; 6-Hydroxymethylacylfulvene
Chemical Name: (5'R)-5'-hydroxy-1'-(hydroxymethyl)-2',5',7'-trimethylspiro[cyclopropane-1,6'-indene]-4'-one
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M.F/Formula | C15H18O3 |
M.W/Mr. | 246.3 |
InChI | InChI=1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1 |
InChI Key | NICJCIQSJJKZAH-AWEZNQCLSA-N |
Canonical SMILES | CC1=C(C2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C)CO |
Isomeric SMILES | CC1=C(C2=C(C3(CC3)[C@@](C(=O)C2=C1)(C)O)C)CO |
2. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
3. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
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