Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.
CAT No: R1468
CAS No:103131-69-7
Synonyms/Alias:Kinetensin;103131-69-7;Kinetensin (human);Ile-ala-arg-arg-his-pro-tyr-phe-leu;IARRHPYFL;h-ile-ala-arg-arg-his-pro-tyr-phe-leu-oh;I-A-R-R-H-P-Y-F-L;CHEBI:80144;DTXSID00145667;L-Ile-L-Ala-L-Arg-L-Arg-L-His-L-Pro-L-Tyr-L-Phe-L-Leu;L-isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-leucine;MFCD00167613;DTXCID5068158;(2R)-2-((2R)-2-((2S)-2-(((2S)-1-((2S)-2-((2R)-2-((2S)-2-((2R)-2-((2S,3S)-2-amino-3-methylpentanamido)propanamido)-5-carbamimidamidopentanamido)-5-carbamimidamidopentanamido)-3-(1H-imidazol-5-yl)propanoyl)pyrrolidin-2-yl)formamido)-3-(4-hydroxyphenyl)propanamido)-3-phenylpropanamido)-4-methylpentanoic acid;(2R)-2-[(2R)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-[(2S,3S)-2-amino-3-methylpentanamido]propanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]-4-methylpentanoic acid;HY-P1255;AKOS024456852;DA-64746;MS-32027;CS-0029130;G12446;
Kinetensin is a naturally occurring peptide known for its role as a biologically active fragment derived from the larger kininogen precursor. As a member of the kinins family, it exhibits notable activity in modulating physiological processes, particularly in the context of vascular biology, neurobiology, and cellular signaling. Its peptide structure and unique sequence confer specificity in receptor interactions, making it a valuable tool for researchers investigating signal transduction pathways, peptide-receptor dynamics, and regulatory mechanisms in both mammalian and non-mammalian systems. The functional versatility of kinetensin underpins its increasing relevance in biochemical and pharmacological research, where it serves as a model compound for studying peptide-mediated responses and the broader implications of kinin-related signaling.
Signal Transduction Studies: Kinetensin is widely utilized in research focused on elucidating the mechanisms of peptide-mediated signal transduction. Its ability to interact with specific cell surface receptors enables scientists to dissect downstream signaling cascades, such as those involving G-protein coupled receptors or secondary messenger pathways. By applying kinetensin to cultured cells or tissue preparations, researchers can probe the modulation of intracellular calcium flux, kinase activation, and other rapid cellular responses, providing insight into the molecular underpinnings of receptor-ligand interactions.
Vascular Biology Research: The peptide's influence on vascular tone and permeability makes it a valuable probe in cardiovascular and endothelial studies. Experimental models employing kinetensin allow for the assessment of its effects on smooth muscle contraction, endothelial cell function, and the regulation of blood vessel dilation. These investigations are critical for understanding the physiological and pathophysiological roles of kinins in blood pressure regulation, inflammation, and vascular homeostasis.
Neurobiological Investigations: Due to its presence and activity in neural tissues, kinetensin is frequently used in neurobiology to explore its role in neurotransmitter release, synaptic modulation, and neuronal excitability. Studies employing this peptide contribute to the mapping of neuropeptide signaling networks and facilitate the identification of novel modulatory pathways within the central and peripheral nervous systems. Its application in electrophysiological assays and neurochemical analyses advances the understanding of peptide influence on neural communication.
Peptide Structure-Activity Relationship (SAR) Analysis: Kinetensin serves as an important reference compound for structure-activity relationship studies in peptide research. By synthesizing analogs or introducing targeted modifications, researchers can investigate how specific amino acid residues contribute to receptor binding affinity, biological activity, and metabolic stability. Such SAR analyses are essential for the rational design of peptide-based probes, agonists, or antagonists, thereby driving innovation in both basic and applied peptide science.
Peptide Synthesis and Analytical Method Development: The defined sequence and bioactivity of kinetensin make it a standard substrate in the optimization of solid-phase peptide synthesis protocols and purification techniques. It is often employed as a model peptide to benchmark analytical methods, such as high-performance liquid chromatography (HPLC) and mass spectrometry, ensuring accuracy and reproducibility in peptide quantification and identification. These applications are integral to advancing peptide chemistry, facilitating the development of robust workflows for both research and industrial peptide production.
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