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Kisspeptin 234

An analog of kisspeptin 10, and an antagonist of kisspeptin receptor (KISS1, GPR54) that inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH).

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Kisspeptin 234(CAS 1145998-81-7)

CAT No: R0938

CAS No:1145998-81-7

Synonyms/Alias:Kisspeptin 234;1145998-81-7;ANWNGFGWRF;peptide 234;EX-A7717F;HY-P1196;AKOS024457846;P234;PD079684;CS-0028952;S-1145998-81-7;(2S)-N-({[(1S)-1-[({[(1R)-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}butyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}methyl)-2-[(2S)-2-[(2S)-3-carbamoyl-2-[(2R)-2-acetamidopropanamido]propanamido]-3-(1H-indol-3-yl)propanamido]succinamide;

Custom Peptide Synthesis
cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C63H78N18O13
M.W/Mr.
1295.4
Sequence
One Letter Code:ANWNGFGWRF
Three Letter Code:Ac-D-Ala-Asn-Trp-Asn-Gly-Phe-Gly-D-Trp-Arg-Phe-NH2
Labeling Target
Kisspeptin receptor
Appearance
White lyophilised solid
Purity
>98%
Activity
Antagonist
Solubility
-20 °C
InChI
InChI=1S/C63H78N18O13/c1-34(74-35(2)82)56(88)79-50(29-52(65)84)62(94)80-48(27-39-31-71-43-21-12-10-19-41(39)43)61(93)81-49(28-51(64)83)58(90)73-32-53(85)75-46(25-37-16-7-4-8-17-37)57(89)72-33-54(86)76-47(26-38-30-70-42-20-11-9-18-40(38)42)60(92)77-44(22-13-23-69-63(67)68)59(91)78-45(55(66)87)24-36-14-5-3-6-15-36/h3-12,14-21,30-31,34,44-50,70-71H,13,22-29,32-33H2,1-2H3,(H2,64,83)(H2,65,84)(H2,66,87)(H,72,89)(H,73,90)(H,74,82)(H,75,85)(H,76,86)(H,77,92)(H,78,91)(H,79,88)(H,80,94)(H,81,93)(H4,67,68,69)/t34-,44+,45+,46+,47-,48+,49+,50+/m1/s1
InChI Key
IUPKBWSKNCAQJQ-JYYYXURSSA-N
Isomeric SMILES
C[C@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N[C@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N)NC(=O)C

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