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KSL 128114

KSL 128114 is a designed cationic peptide with alternating hydrophobic and lysine residues that encourage amphipathic helix formation. Such topology promotes interaction with bacterial-mimetic membranes in vitro. Researchers investigate its folding, aggregation, and surface-disruption properties. Applications include antimicrobial-peptide modeling, membrane-activity profiling, and sequence optimization.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R2806

Synonyms/Alias:HY-P10331;KSL 128114

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cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C96H165N39O21
M.W/Mr.
2201.6
Sequence
One Letter Code:RRRGRKKRRSHWXXDI
Three Letter Code:Ac-D-Arg-Arg-D-Arg-Gly-D-Arg-Lys-D-Lys-Arg-D-Arg-Ser-His-Trp-Gly(tBu)-Chg-Asp-Ile-OH
InChI
InChI=1S/C96H165N39O21/c1-7-51(2)72(89(155)156)133-84(150)68(45-71(139)140)131-87(153)73(53-23-9-8-10-24-53)134-88(154)74(96(4,5)6)135-85(151)66(43-54-46-118-57-26-12-11-25-56(54)57)129-83(149)67(44-55-47-111-50-120-55)130-86(152)69(49-136)132-82(148)65(34-22-42-117-95(109)110)128-81(147)64(33-21-41-116-94(107)108)127-79(145)62(28-14-16-36-98)125-78(144)61(27-13-15-35-97)124-77(143)60(31-19-39-114-92(103)104)122-70(138)48-119-75(141)58(29-17-37-112-90(99)100)123-80(146)63(32-20-40-115-93(105)106)126-76(142)59(121-52(3)137)30-18-38-113-91(101)102/h11-12,25-26,46-47,50-51,53,58-69,72-74,118,136H,7-10,13-24,27-45,48-49,97-98H2,1-6H3,(H,111,120)(H,119,141)(H,121,137)(H,122,138)(H,123,146)(H,124,143)(H,125,144)(H,126,142)(H,127,145)(H,128,147)(H,129,149)(H,130,152)(H,131,153)(H,132,148)(H,133,150)(H,134,154)(H,135,151)(H,139,140)(H,155,156)(H4,99,100,112)(H4,101,102,113)(H4,103,104,114)(H4,105,106,115)(H4,107,108,116)(H4,109,110,117)/t51-,58+,59+,60+,61-,62+,63-,64-,65+,66-,67-,68-,69-,72-,73-,74+/m0/s1
InChI Key
JHIMDMTVBCBWIO-UJEPQUICSA-N

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