L-HISTIDINE:HCL:H2O (RING-2,4-D2; ALPHA, BETA, BETA-D3) is a deuterium-labeled free histidine amino acid salt in which the imidazole ring bears D2 at the 2- and 4-positions and the α and β positions are enriched with three additional deuterium atoms, while the compound is present as a hydrochloride hydrate. The molecule contains an amino group and a carboxyl group typical of amino acids, with the side chain featuring an imidazole ring that can act as a protonatable functionality, and the HCl and H2O components establish the salt/hydrate form without masking the free amino and carboxyl groups. This labeled histidine is used in isotopic tracing, NMR/IR/HRMS-based analytical method development, and peptide or protein labeling workflows where retention of the imidazole ring and backbone positions under isotopic substitution is required for quantitative or structural studies.
CAT No: L-Iso-0315
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