Laminin (925-933) is a peptide derived from residues 925-933 of the Laminin B1 chain that binds to the laminin receptor.
CAT No: R1476
CAS No:110590-60-8
Synonyms/Alias:Laminin (925-933);110590-60-8;Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg;(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid;HY-P0131;MFCD00076474;DB-273475;CS-0019775;Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg, >=90% (HPLC);
Laminin 925-933 is a synthetic peptide fragment derived from the laminin protein, a major component of the extracellular matrix that plays a critical role in cell adhesion, migration, differentiation, and tissue organization. Representing a specific amino acid sequence within the laminin α1 chain, this peptide is of significant interest for its ability to mimic key bioactive domains involved in cell-matrix interactions. Its biochemical properties make it a valuable tool for researchers investigating cellular signaling pathways, tissue engineering strategies, and the molecular mechanisms underlying cell behavior in response to extracellular cues.
Cell Adhesion Studies: As a functionally active laminin-derived peptide, Laminin 925-933 is widely utilized in studies examining cell adhesion processes. By incorporating this sequence into in vitro assays or substrate coatings, researchers can evaluate the specific interactions between cells and laminin motifs, providing insight into integrin-mediated adhesion mechanisms. Such investigations are essential for understanding how cells recognize and bind to extracellular matrix components, which has broad implications for developmental biology and regenerative medicine.
Cell Migration Assays: The peptide's capacity to recapitulate laminin's migratory cues enables its use in cell migration and wound healing models. By supplementing culture systems or microenvironments with Laminin 925-933, scientists can assess how distinct laminin domains influence directed cell movement. These experiments help delineate the molecular drivers of tissue remodeling, angiogenesis, and cancer metastasis, offering a controlled platform for dissecting the contributions of specific extracellular matrix sequences to migratory behavior.
Receptor-Ligand Interaction Research: Laminin 925-933 is instrumental in characterizing the binding affinities and specificities of cell surface receptors, particularly integrins and other laminin-binding proteins. By serving as a defined ligand in binding assays or surface plasmon resonance studies, the peptide allows for precise mapping of receptor recognition sites and downstream signaling events. Such applications are critical for elucidating the structural and functional relationships between extracellular matrix components and their cellular effectors.
Tissue Engineering and Biomaterials Development: Incorporation of Laminin 925-933 into biomaterial scaffolds or surface coatings has proven valuable for enhancing the bioactivity of synthetic substrates. Its presence can promote cell attachment, proliferation, and differentiation in engineered tissue constructs, thereby improving the integration and functionality of biomaterials designed for regenerative applications. Researchers leverage this peptide to tailor the biological performance of hydrogels, films, and three-dimensional scaffolds for specific cell types or tissue models.
Signal Transduction Analysis: The defined sequence of Laminin 925-933 provides a controlled means to probe downstream signaling pathways activated by laminin engagement. By selectively stimulating cells with this peptide, investigators can monitor the activation of intracellular cascades such as MAPK, PI3K/Akt, or focal adhesion kinase pathways. This approach enables detailed dissection of the molecular events triggered by extracellular matrix recognition, supporting the development of targeted strategies for modulating cell fate and function in vitro.
1. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
3. Emu oil in combination with other active ingredients for treating skin imperfections
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More