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LEAP-1, Hepcidin, human

This 25 amino acid residues Liver-Expressed Antimicrobial Peptide 1 (LEAP-1) is also known as hepcidin. LEAP-1 is a liver-specific peptide, but may be detected in the heart and brain at a lesser amount.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: AF3346

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cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.W/Mr.
2789.4
Sequence
One Letter Code: DTHFPICIFCCGCCHRSKCGMCCKT (Disulfide bridges: 7-23, 10-13, 11-19, 14-22)
Three Letter Code: H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH(Disulfide bridges:7-23,10-13,11-19,14-22)
References
Krause, A. et al. Prot. Sci. 12, 143 (2003), Kluver, E. et al. J. Pept. Res. 59, 241(2002), Hunter, H. et al . J. Biol. Chem. 277, 37597 (2002).

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