Leupeptin Hemisulfate is a reversible, competitive inhibitor of serine/cysteine protease, which inhibits cathepsins B, H, L and S, calpain and trypsin. It is used as antioxidant and anti-inflammatory agent.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
Synonyms/Alias | Acetyl-L-leucyl-L-leucyl-L-argininal . hemisulfat |
M.F/Formula | C20H38N6O4.½H2SO4 |
M.W/Mr. | 475.04 |
Sequence | LLR(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal) |
Labeling Target | Cathepsin |
Appearance | White to off-white powder. |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Inhibitor |
Long-term Storage Conditions | Soluble in DMSO |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Solubility | -20 °C |
BoilingPoint | N/A |
ShelfLife | >2 years if stored properly |
Melting Point | N/A |
2. The spatiotemporal control of signalling and trafficking of the GLP-1R
4. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
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