LGnRH-III, lamprey, an isoform of GnRH isolated from the sea lamprey, is a weak GnRH agonist with antitumor activities.
CAT No: R1483
CAS No:147859-97-0
Synonyms/Alias:Peforelin;147859-97-0;LGnRH-III, lamprey;Peforelin [INN];UNII-UJ8NQ5Z0VX;UJ8NQ5Z0VX;Maprelin xp10;Lamprey lh-rh iii;GnRH III;PEFORELIN [MI];pGlu-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2;PYROGLU-HIS-TRP-SER-HIS-ASP-TRP-LYS-PRO-GLY-NH2;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-histidyl-L-alpha-asparagyl-L-tryptophyl-L-lysyl-L-prolylglycinamide;GLYCINAMIDE, 5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-HISTIDYL-L-.ALPHA.-ASPARTYL-L-TRYPTOPHYL-L-LYSYL-L-PROLYL-;GnRH-III;peforelina;peforeline;peforelinum;gonadoliberin-3;Luliberin III;gonadoliberin III;Lhrh(lamprey iii);lamprey GnRH III;DTXCID3086310;Gonadotropin-releasing hormone III;NCGC00167299-01;DA-54904;LHRH (lamprey III) trifluoroacetate salt;G13000;Q27291105;GLYCINAMIDE, 5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-HISTIDYL-L-ALPHA-ASPARTYL-L-TRYPTOPHYL-L-LYSYL-L-PROLYL-;
LGnRH-III, lamprey, is a decapeptide neurohormone belonging to the gonadotropin-releasing hormone (GnRH) family, uniquely identified in the sea lamprey (Petromyzon marinus). Structurally distinct from mammalian GnRH isoforms, LGnRH-III plays a pivotal role in the regulation of reproductive processes in lampreys and other basal vertebrates. Its evolutionary significance, receptor selectivity, and functional divergence make it a valuable molecular tool for comparative endocrinology, peptide receptor studies, and neurobiology research. The compound's precise sequence and biological activity enable researchers to dissect the mechanisms underlying hormone-receptor interactions, evolutionary adaptations in neuroendocrine systems, and the functional diversity of GnRH peptides across species.
Comparative endocrinology: LGnRH-III is widely utilized in studies aimed at understanding the evolution of the hypothalamic-pituitary-gonadal (HPG) axis among vertebrates. By comparing its activity and receptor binding properties with those of mammalian and teleost GnRH isoforms, researchers can elucidate the molecular adaptations that have occurred in the regulation of reproductive hormones. Such investigations provide critical insights into the diversification of neuroendocrine signaling pathways and the functional consequences of sequence variation among GnRH peptides.
Receptor pharmacology: The peptide serves as a highly specific ligand for lamprey GnRH receptors, facilitating detailed analyses of ligand-receptor interactions, signal transduction, and receptor subtype selectivity. Synthetic LGnRH-III is frequently employed in binding assays, G-protein activation studies, and downstream signaling investigations to characterize receptor affinities, activation profiles, and structure-activity relationships. These studies advance the understanding of peptide hormone recognition and inform the rational design of selective GnRH analogs for research applications.
Peptide synthesis and analog development: LGnRH-III provides a valuable template for the design and synthesis of novel peptide analogs with tailored biological activities. Its unique amino acid sequence and functional properties are exploited in structure-activity relationship (SAR) studies, enabling the identification of key residues involved in receptor activation and specificity. Researchers leverage these insights to engineer modified peptides for probing neuroendocrine function or for developing research reagents with enhanced stability and selectivity.
Neurobiology and signaling pathway research: As a model neuropeptide, lamprey LGnRH-III is instrumental in exploring the mechanisms of neuropeptide release, transport, and integration within the central nervous system. Its application in ex vivo brain slice preparations, neuronal culture systems, and in vivo lamprey models allows for the dissection of neural circuits governing reproductive behavior and hormone secretion. These studies contribute to a broader understanding of how neuropeptides modulate physiological and behavioral processes in both ancestral and derived vertebrate lineages.
Analytical and immunological assay development: The availability of synthetic LGnRH-III supports the development of sensitive analytical techniques and immunoassays for detecting endogenous GnRH variants in lamprey tissues and biological fluids. Employing this peptide as a standard or immunogen, researchers can generate highly specific antibodies and calibrators, enabling accurate quantification of neurohormone levels and facilitating ecological, developmental, and physiological studies in lamprey and related species. This analytical capability is essential for advancing research in environmental endocrinology, reproductive biology, and evolutionary physiology.
2. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
3. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More