M2e, human is an extracellular peptide segment containing acidic, polar, and hydrophobic residues arranged to model membrane-associated structures. The sequence supports investigations of helix propensity, solvent-driven folding, and ligand recognition. Researchers use it to map conserved epitopes and structural transitions. Its simplicity enhances analytical clarity.
CAT No: R2264
CAS No:251359-24-7
Synonyms/Alias:M2e, human;251359-24-7;AKOS040744278;DA-75228;
M2e, human is a synthetic peptide corresponding to the extracellular domain of the matrix protein 2 (M2) from the human influenza A virus. As a highly conserved region among various influenza A strains, the M2e peptide has become a focal point in virology and immunological research due to its unique sequence stability and surface exposure on the viral envelope. Its biochemical properties allow it to serve as a valuable molecular tool in studies of viral infection mechanisms, immune recognition, and peptide-based assay development. Researchers utilize this peptide to dissect host-pathogen interactions, explore antiviral strategies, and develop diagnostic reagents, capitalizing on its defined structure and relevance to influenza biology.
Antigenicity studies: The M2e peptide is widely employed as a model antigen in immunological research to investigate immune responses against influenza A virus. Its conserved sequence and extracellular localization make it an ideal candidate for mapping B-cell and T-cell epitopes, evaluating antibody specificity, and characterizing the kinetics of immune recognition. These studies can provide critical insights into the molecular basis of host defense mechanisms and inform the design of immunogens for experimental purposes.
Vaccine research and development: Due to its high degree of conservation across influenza A strains, the M2e sequence is frequently incorporated into experimental vaccine constructs as a universal antigenic target. It is used in the development and optimization of peptide-based vaccine candidates, serving as a scaffold for the presentation of conserved viral epitopes. By facilitating the assessment of immunogenicity in vitro and in animal models, the peptide aids in the identification of promising vaccine platforms and adjuvant combinations that elicit robust and broad-spectrum immune responses.
Monoclonal antibody screening: The synthetic M2e peptide is an essential reagent for the screening and characterization of monoclonal antibodies directed against the influenza A virus. It enables high-throughput binding assays, epitope mapping, and affinity measurements, supporting the selection and engineering of antibody candidates with high specificity and cross-reactivity. These applications are crucial for the development of research tools, diagnostic reagents, and potential antiviral agents targeting conserved viral domains.
Diagnostic assay development: The defined structure and immunogenic properties of M2e make it a valuable component in the design of influenza detection assays. It is utilized as a capture antigen in enzyme-linked immunosorbent assays (ELISAs), lateral flow devices, and other immunoassay platforms to detect anti-influenza antibodies in biological samples. The use of this peptide enhances assay specificity and enables the monitoring of exposure or immune status in research settings, contributing to the advancement of influenza surveillance and serological studies.
Epitope mapping and structure-function analysis: Researchers employ the M2e peptide to elucidate the structural determinants of antibody and receptor binding, as well as to dissect the functional roles of conserved viral sequences. Through mutagenesis, peptide array analysis, and biophysical characterization, the peptide facilitates a detailed understanding of how specific amino acid residues contribute to molecular recognition events. These investigations support efforts to rationally design improved immunogens and to better understand the molecular underpinnings of viral persistence and immune evasion.
By providing a well-defined, highly relevant peptide sequence, M2e, human serves as a versatile and indispensable tool for a wide range of influenza-related research applications. Its use spans fundamental studies of viral biology and immune mechanisms to the development of innovative diagnostic and vaccine technologies, underscoring its significance in both academic and applied scientific contexts.
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