Macimorelin Acetate features a peptide-derived scaffold designed to probe receptor-interaction determinants. Hydrophobic and heterocyclic elements shape its conformational flexibility. Researchers assess its dynamic structural transitions. Applications include ligand-optimization efforts, structural mapping, and peptide-based chemical biology research.
CAT No: R2695
CAS No:945212-59-9
Synonyms/Alias:Macimorelin acetate;Macrilen;D-87575 acetate;ARD 07 acetate;EP 1572 acetate;UNII-AQZ1003RMG;Macimorelin acetate [USAN];AQZ1003RMG;945212-59-9;AEZS 130;Aib-Trp-gTrp-CHO acetate;Macimorelin (acetate);ARD-07 ACETATE;EP-1572 ACETATE;DTXSID40241516;Macimorelin acetate (USAN);D-Tryptophanamide, 2-methylalanyl-N-((1R)-1-(formylamino)-2-(1H-indol-3-yl)ethyl)-, acetate (1:1);acetic acid;2-amino-N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide;N2-(2-amino-2-methylpropanoyl-N1-((1R)-1-formamido-2-(1H-indol-3-yl)ethyl)- D-tryptophanamide acetate;Macrilen (TN);CHEMBL2364617;MACIMORELIN ACETATE [MI];DTXCID70164007;HY-14820A;MACIMORELIN ACETATE [WHO-DD];MACIMORELIN ACETATE [ORANGE BOOK];DA-55160;CS-0027172;D10562;Q27274071;N2-(2-AMINO-2-METHYLPROPANOYL-N1-((1R)-1-FORMAMIDO-2-(1H-INDOL-3-YL)ETHYL)-D-TRYPTOPHANAMIDE ACETATE;
Macimorelin Acetate is a synthetic peptide that functions as a potent, orally active growth hormone secretagogue. Structurally designed to mimic the endogenous ghrelin peptide, it binds selectively to the growth hormone secretagogue receptor (GHS-R1a), stimulating growth hormone (GH) release via a well-characterized signaling cascade. Its biochemical profile and receptor specificity have made it a valuable tool in endocrinological research, particularly in studies focused on the regulation of GH secretion, hypothalamic-pituitary axis dynamics, and metabolic signaling pathways. As a stable peptide with high receptor affinity, Macimorelin Acetate enables precise interrogation of GH-related mechanisms in experimental settings, supporting a range of advanced research applications.
Endocrine Function Research: Macimorelin Acetate is widely utilized in the investigation of growth hormone regulatory pathways. By acting as a selective agonist at the GHS-R1a receptor, it provides a controlled means to stimulate endogenous GH release in vitro and in vivo. Researchers employ this peptide to dissect the molecular mechanisms underlying GH secretion, explore feedback regulation within the hypothalamic-pituitary axis, and elucidate the physiological consequences of modulating the ghrelin-GHS-R1a pathway. Its use facilitates the study of hormonal interplay and signaling events that govern growth, metabolism, and energy homeostasis.
Peptide Receptor Pharmacology: The well-defined receptor specificity of Macimorelin Acetate makes it a model ligand for characterizing GHS-R1a pharmacodynamics and downstream signaling events. In receptor binding assays, signal transduction studies, and structure-activity relationship analyses, this compound serves as a reference agonist to benchmark the activity of novel secretagogues or antagonists. Its application extends to the mapping of receptor distribution, assessment of ligand-receptor interactions, and investigation of receptor desensitization or internalization processes, contributing to a deeper understanding of peptide hormone receptor biology.
Metabolic Pathway Analysis: As a functional analog of ghrelin, Macimorelin Acetate is instrumental in studies examining the metabolic roles of growth hormone and ghrelin signaling. Researchers leverage its activity to probe the impact of GH on glucose metabolism, lipid mobilization, and energy expenditure in cellular and animal models. By selectively activating the GHS-R1a pathway, it enables the dissection of metabolic responses, clarifies the crosstalk between endocrine and metabolic systems, and supports the development of mechanistic models of metabolic regulation.
Peptide Stability and Bioavailability Studies: Macimorelin Acetate's robust stability and oral bioactivity make it a valuable reference compound for evaluating peptide modification strategies. Scientists use it to compare the pharmacokinetic properties of novel peptide analogs, assess resistance to enzymatic degradation, and optimize formulation approaches for oral peptide delivery. Its established profile aids in the development of next-generation secretagogues with improved bioavailability and therapeutic potential, informing both basic and translational research in peptide chemistry.
Analytical Method Development: The physicochemical and biological characteristics of Macimorelin Acetate support its use as a standard in analytical method validation. Laboratories employ it to calibrate and optimize chromatographic, mass spectrometric, and immunoassay techniques for the quantification of peptide secretagogues in complex biological matrices. Its application in assay development ensures accurate measurement of GH secretagogues, supports pharmacokinetic and pharmacodynamic studies, and enhances the reliability of peptide analysis in research and development workflows.
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