Melanoma-associated antigen 2; MAGE-2
CAT No: ta-453
Synonyms/Alias:Melanoma-associated antigen 2 (212-220); MAGE-2 (212-220)
MAGE-2 (212-220) is a synthetic peptide fragment derived from the melanoma-associated antigen gene family, specifically spanning amino acid residues 212 to 220. As a member of the MAGE (Melanoma Antigen Gene) protein family, this peptide represents a highly characterized epitope relevant to immunological studies, tumor antigen research, and peptide-based assay development. Its well-defined sequence and immunogenic properties make it an important tool for researchers investigating antigen presentation, T-cell recognition, and cancer immunology. The unique characteristics of this peptide enable precise interrogation of peptide-MHC interactions and facilitate the study of antigen-specific immune responses in a variety of experimental systems.
Epitope Mapping: MAGE-2 (212-220) is frequently utilized in epitope mapping experiments to identify and characterize T-cell epitopes recognized by cytotoxic T lymphocytes (CTLs) in the context of tumor-associated antigens. Its defined sequence allows researchers to dissect the specificity and binding affinity of T-cell receptors (TCRs) for this particular MAGE-derived epitope. Such studies are instrumental in advancing the understanding of immune recognition mechanisms and the molecular basis of tumor antigenicity, supporting the rational design of immunotherapeutic strategies.
Peptide-MHC Binding Assays: The peptide is widely employed in peptide-major histocompatibility complex (MHC) binding assays to evaluate the affinity and stability of peptide-MHC interactions. By loading MAGE-2 (212-220) onto specific MHC class I molecules, researchers can assess the efficiency of antigen presentation and the structural determinants that influence peptide binding. These assays provide critical insights into antigen processing and presentation pathways, facilitating the development of predictive algorithms for neoantigen identification and vaccine design.
T-cell Activation Studies: MAGE-2 (212-220) serves as a model antigen in T-cell activation assays, enabling the functional analysis of antigen-specific T-cell responses. When presented by appropriate antigen-presenting cells, the peptide can stimulate T-cell proliferation, cytokine secretion, and cytolytic activity in vitro. Such experiments are essential for evaluating the immunogenic potential of tumor antigens, screening T-cell clones for specificity, and optimizing protocols for adoptive cell therapy research.
Immunological Assay Development: The defined structure and immunological relevance of MAGE-2 (212-220) make it a valuable reagent in the development and validation of immunoassays, including ELISPOT, intracellular cytokine staining, and tetramer staining techniques. Incorporation of this peptide into assay platforms enables sensitive detection of antigen-specific T-cells, quantification of immune responses, and monitoring of immune repertoire dynamics in experimental systems. Its use supports the standardization and reproducibility of immunological assays across laboratories.
Peptide Synthesis and Structural Analysis: In addition to its immunological applications, MAGE-2 (212-220) is frequently used as a reference standard in peptide synthesis and structural studies. Its well-characterized sequence provides a benchmark for evaluating the efficiency and fidelity of solid-phase peptide synthesis protocols. Moreover, structural analyses using techniques such as mass spectrometry or NMR spectroscopy benefit from the availability of this defined peptide, supporting quality control and method development in peptide chemistry research.
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