α-Melanocyte-Stimulating Hormone (MSH), amide

α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
α-Melanocyte-Stimulating Hormone (MSH), amide(CAS 581-05-5)

CAT No: R1763

CAS No:581-05-5

Synonyms/Alias:581-05-5;Intermedin;MELANOTROPIN;a-Melanotropin (swine);Melanotropin alpha;Melantropin;CZEN-002;.alpha.-msh;.alpha.-melanotropin;.alpha.-melanotropin (ox);.alpha.-melanotropin (human);.alpha.-melanotropin (sheep);N-acetyl-acth(1-13)-amide;OVF025LA77;alpha-Melanotropin (human);alpha-Melanotropin (ox);alpha-Melanotropin (pig);alpha-Melanotropin (swine);UNII-OVF025LA77;alpha-Intermedin;Intermedine [INN];Ba 33761;MFCD00133062;alpha-Melanotropin (Macaca nemestrina);alpha-Melanotropin I (Oncorhynchus keta);alpha-1-13-Corticotropin, N-acetyl-13-L-valinamide-;SCHEMBL20548027;SCHEMBL22076809;CHEBI:195325;.ALPHA.-MELANOTROPIN [MI];AKOS024457181;AS-57738;Active principle of the pars intermedia of the pituitary;Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;N-Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-;N-acetyl-L-Ser-L-Tyr-L-Ser-L-Met-L-alpha-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-valinamide;VALINAMIDE, ACETYL-L-SERYL-L-TYROSYL-L-SERYL-L-METHIONYL-L-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-ARGINYL-L-TRYPTOPHYL-GLYCYL-L-LYSYL-L-PROLYL-, L-;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C77H109N21O19S
M.W/Mr.
1664.9
Sequence
One Letter Code:SYSMEHFRWGKPV
Three Letter Code:Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Biological Activity
Endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
InChI Key
WHNFPRLDDSXQCL-UAZQEYIDSA-N

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