α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
CAT No: R1763
CAS No:581-05-5
Synonyms/Alias:581-05-5;Intermedin;MELANOTROPIN;a-Melanotropin (swine);Melanotropin alpha;Melantropin;CZEN-002;.alpha.-msh;.alpha.-melanotropin;.alpha.-melanotropin (ox);.alpha.-melanotropin (human);.alpha.-melanotropin (sheep);N-acetyl-acth(1-13)-amide;OVF025LA77;alpha-Melanotropin (human);alpha-Melanotropin (ox);alpha-Melanotropin (pig);alpha-Melanotropin (swine);UNII-OVF025LA77;alpha-Intermedin;Intermedine [INN];Ba 33761;MFCD00133062;alpha-Melanotropin (Macaca nemestrina);alpha-Melanotropin I (Oncorhynchus keta);alpha-1-13-Corticotropin, N-acetyl-13-L-valinamide-;SCHEMBL20548027;SCHEMBL22076809;CHEBI:195325;.ALPHA.-MELANOTROPIN [MI];AKOS024457181;AS-57738;Active principle of the pars intermedia of the pituitary;Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;N-Ac-L-Ser-L-Tyr-L-Ser-L-Met-L-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-;N-acetyl-L-Ser-L-Tyr-L-Ser-L-Met-L-alpha-Glu-L-His-L-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-valinamide;VALINAMIDE, ACETYL-L-SERYL-L-TYROSYL-L-SERYL-L-METHIONYL-L-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-ARGINYL-L-TRYPTOPHYL-GLYCYL-L-LYSYL-L-PROLYL-, L-;
α-Melanocyte-Stimulating Hormone (MSH), amide is a synthetic peptide belonging to the melanocortin family, recognized for its role in modulating pigmentation, energy homeostasis, and inflammatory responses in biological systems. As an amidated form of the endogenous α-MSH, it exhibits enhanced stability and affinity for melanocortin receptors, making it a valuable tool in biochemical and physiological research. Its ability to interact specifically with a spectrum of melanocortin receptor subtypes positions it as a critical reagent for dissecting signaling pathways involved in pigmentation, neuroendocrine regulation, and immunomodulation. The peptide's well-characterized structure and functional relevance underpin its widespread application in experimental studies focused on peptide signaling mechanisms and receptor pharmacology.
Receptor Pharmacology: In the field of receptor biology, α-Melanocyte-Stimulating Hormone, amide serves as a high-affinity ligand for melanocortin receptors, particularly MC1R, MC3R, MC4R, and MC5R. Researchers utilize this peptide to probe receptor-ligand interactions, characterize receptor subtypes, and delineate downstream signal transduction pathways. Its application enables the study of receptor binding kinetics, agonist potency, and receptor selectivity, facilitating a deeper understanding of G protein-coupled receptor (GPCR) pharmacology in both in vitro and ex vivo systems.
Pigmentation Research: The peptide is extensively employed in studies investigating the molecular regulation of melanogenesis. By stimulating melanocortin 1 receptor (MC1R) on melanocytes, α-MSH, amide induces eumelanin synthesis, allowing researchers to model and quantify pigment production in cultured cells or tissue explants. Such studies are pivotal for elucidating the genetic and biochemical determinants of skin, hair, and eye color, as well as for exploring the impact of genetic mutations or environmental factors on pigmentation pathways.
Neuroendocrine Function Studies: As a neuropeptide, α-MSH, amide is integral to research on hypothalamic regulation of appetite, energy expenditure, and metabolic homeostasis. Its application in neuronal cell cultures and animal models aids in mapping neural circuits and signaling cascades involved in feeding behavior, satiety, and energy balance. These investigations are essential for understanding the central mechanisms that govern metabolic processes and for identifying molecular targets relevant to obesity and metabolic syndrome research.
Immunomodulation Analysis: The immunoregulatory properties of α-MSH, amide are of significant interest in immunology and inflammation research. The peptide's ability to modulate cytokine production, inhibit pro-inflammatory signaling, and promote anti-inflammatory responses is leveraged in studies aimed at dissecting the cellular and molecular mechanisms underlying immune tolerance and inflammatory resolution. Its use in immune cell assays provides valuable insights into the cross-talk between neuropeptides and immune mediators.
Peptide Structure-Activity Relationship (SAR) Studies: The amidated form of α-MSH is frequently utilized as a reference compound in structure-activity relationship investigations. By comparing its biological activity to that of analogs with specific sequence modifications or alternative terminal groups, researchers can identify critical residues and structural features required for receptor binding and functional activity. These SAR studies inform the rational design of novel melanocortin ligands with tailored pharmacological profiles for experimental and industrial research applications.
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