MEN 11270 is a peptide antagonist of the B2 bradykinin receptor (pKi = 10.3) and conformationally constrained cyclized analog of HOE 140 (Cat. No. 3014). It can blocks hypotension and bronchoconstriction in vivo.
CAT No: R0807
CAS No:235082-52-7
Synonyms/Alias:MEN 11270;235082-52-7;MEN-11270;KJA08252;H-D-Arg-Arg-Pro-Hyp-Gly-Thi-c(Dab-DTic-Oic-Arg)c(7gamma-10alpha);AKOS024457909;PD079706;
MEN 11270 is a synthetic peptide compound recognized for its role as a selective melanocortin-4 receptor (MC4R) antagonist. Structurally designed to interact with the melanocortin system, it serves as a valuable molecular tool in neuroendocrine and metabolic research. Its specificity for MC4R allows researchers to dissect the physiological and pathophysiological functions of this receptor subtype, which is implicated in the regulation of energy homeostasis, appetite, and neuroendocrine signaling. MEN 11270's unique pharmacological profile enables precise modulation of melanocortin pathways, making it a critical asset in studies aiming to unravel complex neurobiological mechanisms.
Receptor pharmacology studies: MEN 11270 is widely utilized in receptor binding and signaling assays to characterize the functional dynamics of the melanocortin-4 receptor. By acting as a competitive antagonist, it enables researchers to selectively inhibit MC4R-mediated responses in vitro and in vivo. This targeted blockade facilitates the investigation of downstream signaling cascades, receptor-ligand interactions, and the physiological roles of MC4R in neural and peripheral tissues. The compound's high selectivity is particularly advantageous in distinguishing MC4R-mediated effects from those of other melanocortin receptor subtypes.
Metabolic regulation research: The compound is instrumental in metabolic studies focused on elucidating the central regulation of energy balance and feeding behavior. By antagonizing MC4R, MEN 11270 allows for the assessment of the receptor's contribution to appetite control, energy expenditure, and nutrient partitioning. Researchers employ it to model conditions of altered melanocortin signaling, thereby advancing the understanding of obesity, cachexia, and other metabolic disorders at the molecular and physiological levels.
Neuroendocrine function analysis: MEN 11270 serves as a powerful tool in the exploration of neuroendocrine pathways modulated by melanocortin signaling. Its ability to selectively inhibit MC4R is leveraged to dissect the receptor's involvement in the regulation of hypothalamic-pituitary-adrenal (HPA) axis activity, stress responses, and hormonal secretion patterns. Such studies are critical for mapping the neurochemical circuits underlying stress adaptation, energy homeostasis, and neurohormonal integration.
Behavioral neuroscience investigations: In the field of behavioral neuroscience, MEN 11270 is employed to probe the role of MC4R in modulating complex behaviors such as reward processing, motivation, and emotional regulation. By selectively blocking MC4R, researchers can isolate the receptor's influence on neural circuits governing mood, anxiety, and reward-driven actions. These applications contribute to a deeper understanding of how melanocortin signaling interfaces with behavioral phenotypes and neuropsychiatric conditions.
Peptide drug discovery and development: As a model MC4R antagonist, MEN 11270 is also utilized in early-stage screening and structure-activity relationship (SAR) studies aimed at developing novel peptide-based modulators of the melanocortin system. Its well-characterized pharmacological properties make it a reference compound for benchmarking the efficacy, selectivity, and mechanism of action of new synthetic peptides targeting MC4R. This application supports the advancement of research tools and potential therapeutic candidates in the field of neuroendocrinology and metabolic regulation.
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