Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.
CAT No: R1536
CAS No:87096-84-2
Synonyms/Alias:Neuromedin B;87096-84-2;NeuromedinB,Porcine;CHEMBL403317;Gly-asn-leu-trp-ala-thr-gly-his-phe-met-NH2;Compound NMB;GTPL3771;[125I]-BH-NMB;[125I]-Bolton Hunter neuromedin B;BDBM50071745;Neuromedin B (trifluoroacetate salt);AKOS015902909;AKOS040764009;[125I]BH-NMB (human, mouse, rat);NCGC00167187-01;TS-10381;Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2(Neuromedin B);Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2;GNLWATGHFM-NH2;(2S)-2-(2-aminoacetamido)-N-[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2R)-1-[({[(1S)-1-{[(1S)-1-{[(1S)-1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(imidazol-4-yl)ethyl]carbamoyl}methyl)carbamoyl]-2-hydroxypropyl]carbamoyl}ethyl]carbamoyl}-2-(indol-3-yl)ethyl]carbamoyl}-3-methylbutyl]succinamide;
Neuromedin B is a bioactive peptide belonging to the bombesin-like peptide family, recognized for its significant role as a neuropeptide in mammalian systems. Structurally, it is characterized by a conserved amino acid sequence that enables interaction with specific G protein-coupled receptors, particularly the neuromedin B receptor (NMBR). This peptide is widely distributed in the central nervous system and peripheral tissues, where it functions as a key modulator of neurotransmission, neuroendocrine signaling, and various physiological processes. Its well-defined structure and receptor specificity make it a valuable tool for elucidating peptide-receptor interactions and dissecting signaling pathways relevant to neurobiology and gastrointestinal physiology.
Receptor Pharmacology Studies: Neuromedin B is extensively utilized in receptor binding and pharmacological assays to characterize the functional properties of the NMBR and related bombesin receptors. Researchers employ synthetic forms of the peptide to investigate ligand-receptor affinity, signal transduction mechanisms, and downstream effector responses. These studies provide critical insights into the selectivity and potency of neuromedin B analogs, aiding in the design of receptor-targeted probes and the development of novel modulators for experimental applications.
Neurobiology Research: Due to its prominent expression in the brain, neuromedin B serves as an important molecular tool for exploring neural circuit modulation, neurotransmitter release, and synaptic plasticity. Experimental models leverage the peptide to assess its influence on neuronal excitability, synaptic transmission, and neuropeptide signaling cascades. Such investigations contribute to a deeper understanding of the physiological roles of bombesin-like peptides in sensory processing, behavioral regulation, and neuroendocrine integration.
Gastrointestinal Physiology: The peptide is frequently employed in studies of gastrointestinal motility, secretion, and hormone release. By acting on specific receptors in the gut, neuromedin B modulates smooth muscle contraction, regulates gastric acid secretion, and influences the release of digestive peptides. Experimental applications in isolated tissue preparations or cell-based assays enable researchers to delineate the mechanisms underlying peptide-mediated control of gastrointestinal function and to identify potential targets for further investigation.
Peptide Structure-Activity Relationship (SAR) Analysis: Neuromedin B provides a robust framework for structure-activity relationship studies aimed at mapping the functional domains essential for receptor activation and biological activity. Systematic modification of the peptide sequence, followed by functional testing, allows for the identification of key residues involved in receptor binding and signaling. These SAR analyses support the rational design of peptide analogs with altered potency, selectivity, or stability, facilitating the development of research tools and molecular probes for advanced peptide biology studies.
Analytical Method Development: The unique physicochemical properties of neuromedin B render it suitable as a reference standard or control in the development and validation of analytical techniques, such as high-performance liquid chromatography (HPLC) and mass spectrometry. Researchers utilize the peptide to optimize detection methods, calibrate analytical instruments, and establish quantitation protocols for bombesin-like peptides in biological samples. These analytical applications are essential for ensuring data quality and reproducibility in peptide quantification and profiling studies.
3. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
4. Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors
5. Cationic cell-penetrating peptides are potent furin inhibitors
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More