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Neurotensin

Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR).

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1549

CAS No:39379-15-2

Synonyms/Alias:NEUROTENSIN;55508-42-4;39379-15-2;Neurotensin 1-13;XHB61LG5QS;CHEMBL407196;Neurotensin (ox);Neurotensin (cattle);CCRIS 3327;[3H]-Neurotensin;11-Tyr-neurotensin;(D-Tyr11)neurotensin;neurotensin (1-13);neurotensin-(1-13);UNII-XHB61LG5QS;Neurotensin, tyr(11)-;Neurotensin, tyrosine(11)-;CHEBI:7542;GTPL1574;GTPL1579;GTPL3830;Neurotensin, >=90% (HPLC);PCJGZPGTCUMMOT-ISULXFBGSA-N;H-Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH;[125I]NT;Neurotensin (ox), 11-D-tyrosine-;BDBM50130880;[3H]neurotensin (human, mouse, rat);[125I]neurotensin (human, mouse, rat);NCGC00167274-01;DA-66045;FN109271;NT(1-13);NS00074250;Q27087905;pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu;Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu;

Chemical Name:(Z)-5-(((Z)-1-((6-amino-1-(2-((Z)-(((Z)-1-((1-(2-((Z)-(((Z)-1-(((Z)-1-((1-carboxy-3-methylbutyl)imino)-1-hydroxy-3-methylpentan-2-yl)imino)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)imino)(hydroxy)methyl)pyrrolidin-1-yl)-5-guanidino-1-oxopentan-2-yl)imino)

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C78H121N21O20
M.W/Mr.
1672.9
Sequence
One Letter Code:XLYENKPRRPYIL
Three Letter Code:H-Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
Application
As a biologically active neuropeptide for proteomics research
Appearance
White to off-white lyophilized solid
Purity
≥97% by HPLC
Length
13
Long-term Storage Conditions
Soluble to 0.70 mg/ml in water
InChI
InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1
InChI Key
PCJGZPGTCUMMOT-ISULXFBGSA-N
Canonical SMILES
CCC(C(/N=C(O)/C(/N=C(O)/C1CCCN1C(C(/N=C(O)/C(/N=C(O)/C2CCCN2C(C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C3CCC(O)=N3)CC(C)C)CC4=CC=C(O)C=C4)CCC(O)=O)CC(O)=N)CCCCN)=O)CCCNC(N)=N)CCCNC(N)=N)=O)CC5=CC=C(O)C=C5)/C(O)=N/C(C(O)=O)CC(C)C)C

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