β-Nicotinamide Mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase. β-NMN has several beneficial pharmacological activities. Mostly mediated by its involvement in NAD+ biosynthesis, including its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity.
CAT No: 10-101-324
CAS No:1094-61-7
Synonyms/Alias:β-NMN, β-Nicotinamide ribose monophosphate, NMN
Chemical Name:3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-pyridinium, inner salt
β-Nicotinamide Mononucleotide (β-NMN) is a bioactive nucleotide derived from ribose and nicotinamide, recognized as a direct precursor to nicotinamide adenine dinucleotide (NAD+). As a pivotal molecule in cellular metabolism, it plays a crucial role in the regulation of energy production, redox reactions, and cellular signaling pathways. Its water solubility and chemical stability make it highly suitable for diverse research and industrial applications, particularly in studies focused on metabolic health, aging, and enzymatic functions. The molecular structure of β-NMN facilitates its efficient incorporation into NAD+ biosynthetic pathways, thereby supporting a range of biochemical processes essential for cell survival and function.
Metabolic Research: β-Nicotinamide Mononucleotide is extensively utilized in metabolic studies to elucidate the mechanisms underlying NAD+ biosynthesis and its impact on cellular energy homeostasis. By supplementing cell cultures or model organisms with β-NMN, researchers can investigate the effects of enhanced NAD+ availability on mitochondrial function, ATP production, and the regulation of metabolic enzymes. This approach enables the dissection of metabolic pathways and the identification of key regulatory nodes implicated in energy balance, obesity, and metabolic syndromes.
Aging and Longevity Research: NMN is a valuable tool in the exploration of aging-related processes, as it directly influences NAD+ levels, which are known to decline with age. In laboratory settings, it is used to assess how restoring NAD+ pools affects cellular senescence, DNA repair mechanisms, and sirtuin activity. These studies provide critical insights into the molecular basis of aging and the role of NAD+ metabolism in maintaining genomic stability, stress resistance, and tissue function over time.
Neuroscience and Neuroprotection: The compound is increasingly employed in neuroscience research to examine its effects on neuronal health, synaptic plasticity, and neuroprotection. By modulating NAD+ concentrations in neural tissue, β-NMN helps researchers delineate the pathways involved in neuronal survival, axonal regeneration, and the response to oxidative stress. Such investigations contribute to a deeper understanding of neurodegenerative processes and the maintenance of cognitive function under stress or injury.
Enzyme Activity Assays: β-NMN serves as a substrate or modulator in a variety of enzyme activity assays, particularly those involving NAD+-dependent enzymes such as sirtuins, PARPs, and dehydrogenases. By providing a readily available precursor for NAD+ synthesis, it allows scientists to study enzyme kinetics, cofactor requirements, and the regulation of post-translational modifications in vitro. These assays are fundamental for characterizing enzyme mechanisms and for the discovery of novel modulators of NAD+-dependent pathways.
Nutraceutical and Functional Ingredient Development: Beyond basic research, β-Nicotinamide Mononucleotide is gaining attention as a functional ingredient in the development of nutraceuticals and dietary supplements. Its role as a NAD+ precursor positions it as a promising candidate for formulations aimed at supporting cellular metabolism and promoting overall vitality. Research and development teams leverage its biochemical properties to design innovative products that target energy metabolism and cellular resilience, thereby expanding its utility in the wellness and health-support sector.
Analytical Chemistry and Quantification: In analytical chemistry, NMN is employed as a reference standard or analyte for the quantification of NAD+ metabolites in biological samples. Advanced techniques such as liquid chromatography-mass spectrometry (LC-MS) utilize this compound to calibrate instruments, validate analytical methods, and ensure accurate measurement of nicotinamide-related metabolites. These applications are critical for pharmacokinetic studies, biomarker discovery, and the assessment of metabolic flux in various experimental models, further highlighting the versatility and research value of β-Nicotinamide Mononucleotide.
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