NP-12

NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy.

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CAT No: R1566

CAS No: 1353564-66-5

Synonyms/Alias: Tideglusib;865854-05-3;NP-12;NP031112;Tideglusib [INN];4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione;NP-031112;tideglusibum;Zentylor;Nypta;NP 031112;UNII-Q747Y6TT42;Q747Y6TT42;TIDEGLUSIB [WHO-DD];CHEBI:147398;DTXSID90235682;4-benzyl-2-(a-naphtyl)-1,2,4-thiadiazolidine-3,5-dione;2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione;4-BENZYL-2-(A-NAPHTHYL)-1,2,4-THIADIAZOLIDINE-3,5-DIONE;4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione;Zentylor nypta;MFCD18633296;1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-;Tideglusib(NP-031112);1353564-66-5;SCHEMBL676929;Tideglusib(NP-031112)?;GTPL6929;CHEMBL3545157;Tideglusib, >=98% (HPLC);DTXCID20158173;EX-A600;HMS3673G17;HMS3744E05;HMS3884J18;4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione;4-benzyl-2-(naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione;BCP06016;Tideglusib,CAS:865854-05-3;BDBM50166940;NSC800950;s2823;AKOS025149085;CCG-267855;CS-0613;DB12129;FT30356;NSC-800950;SB19268;SDCCGSBI-0654483.P001;Tideglusib (NP031112, NP-12);Tideglusib (NP-031112, NP-12);NCGC00386380-06;AC-31056;AS-56156;DA-41071;DA-56282;HY-14872;NS00071037;BRD-K81330143-001-02-2;BRD-K81330143-001-04-8;Q10382411;945421-01-2;

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC19H14N2O2S
M.W/Mr.334.4
SequenceOne Letter Code: H-SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE-NH2
three Letter Code: Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln -Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2
InChIInChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChI KeyPMJIHLSCWIDGMD-UHFFFAOYSA-N

1. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis

2. The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

3. GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats

4. Myotropic activity of allatostatins in tenebrionid beetles

5. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

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