NP-12

Name: NP-12
Brand: Creative Peptides
SKU: R1566
Availability: MadeToOrder

NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1566

CAS No:1353564-66-5

Synonyms/Alias:Tideglusib;865854-05-3;NP-12;NP031112;Tideglusib [INN];4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione;NP-031112;tideglusibum;Zentylor;Nypta;NP 031112;UNII-Q747Y6TT42;Q747Y6TT42;TIDEGLUSIB [WHO-DD];CHEBI:147398;DTXSID90235682;4-benzyl-2-(a-naphtyl)-1,2,4-thiadiazolidine-3,5-dione;2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione;4-BENZYL-2-(A-NAPHTHYL)-1,2,4-THIADIAZOLIDINE-3,5-DIONE;4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione;Zentylor nypta;MFCD18633296;1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-;Tideglusib(NP-031112);1353564-66-5;SCHEMBL676929;Tideglusib(NP-031112)?;GTPL6929;CHEMBL3545157;Tideglusib, >=98% (HPLC);DTXCID20158173;EX-A600;HMS3673G17;HMS3744E05;HMS3884J18;4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione;4-benzyl-2-(naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione;BCP06016;Tideglusib,CAS:865854-05-3;BDBM50166940;NSC800950;s2823;AKOS025149085;CCG-267855;CS-0613;DB12129;FT30356;NSC-800950;SB19268;SDCCGSBI-0654483.P001;Tideglusib (NP031112, NP-12);Tideglusib (NP-031112, NP-12);NCGC00386380-06;AC-31056;AS-56156;DA-41071;DA-56282;HY-14872;NS00071037;BRD-K81330143-001-02-2;BRD-K81330143-001-04-8;Q10382411;945421-01-2;

Custom Peptide Synthesis

cGMP Peptide

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

C19H14N2O2S

M.W/Mr.

334.4

Sequence

One Letter Code: H-SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE-NH2
three Letter Code: Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln -Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2

InChI

InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2

InChI Key

PMJIHLSCWIDGMD-UHFFFAOYSA-N

1. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review

2. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

3. Multifunctional peptide-oligonucleotide conjugate promoted sensitive electrochemical biosensing of cardiac troponin I

4. Effect of Probiotic Lactobacillus plantarum on Streptococcus mutans and Candida albicans Clinical Isolates from Children with Early Childhood Caries

5. Extended exenatide administration enhances lipid metabolism and exacerbates pancreatic injury in mice on a high fat, high carbohydrate diet

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