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This peptide is derived from the Neh2 domain of nuclear factor (erythroid-derived 2)-like 2, or Nrf2. Nrf2 is a bZIP transcription factor that regulates the expression of antioxidative and cytoproptective genes. The DxETGE motif of this peptide binds Keap1 Kelch adaptor protein and displaces Nrf2 from Keap1.
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M.W/Mr. | 1631.9 |
Sequence | One Letter Code: LQLDEETGEFLPIQ Three Letter Code: H-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH |
References | 1.Yokota, S. et al. Biochem Pharmacol 81, 289 (2011); 2. Lo, S-C. et al. EMBO J 25, 3605 (2006). |
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