Nuclear Factor (Erythroid-derived 2) like 2 (74 - 87)

This peptide is derived from the Neh2 domain of nuclear factor (erythroid-derived 2)-like 2, or Nrf2. Nrf2 is a bZIP transcription factor that regulates the expression of antioxidative and cytoproptective genes. The DxETGE motif of this peptide binds Keap1 Kelch adaptor protein and displaces Nrf2 from Keap1.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: X21210

Synonyms/Alias:Nrf2 (74-87); NFE2L2 (74-87)

Custom Peptide Synthesis

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.W/Mr.

1631.9

Sequence

One Letter Code: LQLDEETGEFLPIQ
Three Letter Code: H-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

References

1.Yokota, S. et al. Biochem Pharmacol 81, 289 (2011);
2. Lo, S-C. et al. EMBO J 25, 3605 (2006).

1. Investigating Potential Interactions Between Neurohypophyseal Peptides, their Drug Analogs, and Coagulation Factor VIII

2. Effect of Short-Term Desiccation, Recovery Time, and CAPA-PVK Neuropeptide on the Immune System of the Burying Beetle Nicrophorus vespilloides

3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists

4. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

5. The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

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