OVA Peptide (257-264) is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb.
CAT No: R1583
CAS No:138831-86-4
Synonyms/Alias:138831-86-4;OVA Peptide(257-264);H-SER-ILE-ILE-ASN-PHE-GLU-LYS-LEU-OH;SIINFEKL;1p1z;1p4l;HY-P1489;(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-4-methylpentanoic acid;OVA Peptide(257-264) TFA;OVA Peptide 257-264;Ovalbumin (257-264) (chicken);CHEMBL243289;SCHEMBL15094182;Ovalbumin (257-264) chicken;Ova 257-264;AKOS040759196;OVA peptide (257-264) TFA salt;PP47154;AS-85662;DA-76496;FO109383;CS-0044433;G78424;OT I Peptide; H-SIINFEKL-OH; CRB1000268;Ovalbumin (257-264) (chicken) trifluoroacetate salt;H-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu-OH; H-SIINFEKL-OH;(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S,3S)-2-[(2S)-2-amino-3-hydroxypropanamido]-3-methylpentanamido]-3-methylpentanamido]-3-carbamoylpropanamido]-3-phenylpropanamido]-4-carboxybutanamido]hexanamido]-4-methylpentanoic acid;L-Leucine,l-seryl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-phenylalanyl-L-a-glutamyl-l-lysyl-;
OVA Peptide 257-264 is a synthetic peptide fragment derived from ovalbumin, corresponding to amino acid residues 257 through 264. As a well-characterized epitope, it holds significant relevance in immunological and peptide research, particularly in the study of antigen processing and T cell recognition. Its defined sequence and immunogenic properties make it a staple tool for dissecting cellular immune responses, evaluating antigen-specific T lymphocyte activation, and serving as a benchmark in various experimental systems. The peptide's versatility extends to its use in both basic and applied research settings, supporting investigations into immune mechanisms, peptide-MHC interactions, and the development of immunological assays.
Epitope Mapping: Researchers utilize OVA257-264 as a model antigenic determinant for mapping T cell epitopes. Its precise sequence enables the identification and characterization of peptide-MHC complexes recognized by CD8+ cytotoxic T lymphocytes. By incorporating this peptide into in vitro and in vivo assays, scientists can delineate the specificity and breadth of T cell responses, providing critical insights into antigen recognition and immune repertoire profiling.
Antigen Presentation Studies: The peptide is widely employed in experiments focused on antigen processing and presentation pathways. Due to its defined immunodominance and efficient binding to MHC class I molecules, it serves as a reference substrate for investigating the mechanisms by which peptides are loaded onto MHC molecules and subsequently presented to T cells. These studies are pivotal for understanding the dynamics of immune surveillance, tolerance, and activation.
Immunological Assay Development: OVA257-264 is frequently used as a positive control or calibration standard in a variety of immunological assays, including ELISPOT, intracellular cytokine staining, and cytotoxicity assays. Its robust immunogenicity and well-documented T cell reactivity make it ideal for validating assay performance, optimizing experimental conditions, and benchmarking immune responses in both murine and engineered cellular systems.
Vaccine Design and Evaluation: The peptide's established immunogenic profile supports its application in preclinical vaccine research. It is incorporated into experimental vaccine formulations or delivery systems to assess the induction of antigen-specific cytotoxic T lymphocyte responses. By serving as a model epitope, it enables the comparative evaluation of novel adjuvants, delivery vehicles, and immunization strategies, thereby contributing to the rational design of peptide-based vaccines.
Peptide-MHC Structural Studies: OVA257-264 is instrumental in structural biology research aimed at elucidating the molecular interactions between peptides and major histocompatibility complex molecules. Its use in crystallography and binding assays allows for the detailed analysis of peptide-MHC conformations, stability, and T cell receptor engagement. These investigations advance the fundamental understanding of immune recognition at the molecular level and inform the design of synthetic immunogens with optimized properties.
Through these diverse applications, OVA Peptide 257-264 remains a cornerstone reagent for immunological research, supporting the exploration of T cell biology, antigen presentation mechanisms, and the development of innovative immunoassays and vaccine strategies. Its consistent performance and well-documented properties ensure its ongoing relevance in both foundational and translational research contexts.
1. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
2. The spatiotemporal control of signalling and trafficking of the GLP-1R
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More